Exercise and QUality Diet after Leukemia: A Randomized Weight Loss Trial among Adult Survivors of Childhood Leukemia in the Childhood Cancer Survivor Study

Author:

Friedman Danielle N.12ORCID,Chou Joanne F.1ORCID,Clark Jeanne M.3ORCID,Moskowitz Chaya S.12ORCID,Ford Jennifer S.4ORCID,Armstrong Gregory T.5ORCID,Mubdi Nidha Z.1ORCID,McDonald Aaron5ORCID,Nathan Paul C.6ORCID,Sklar Charles A.12ORCID,Ramanathan Lakshmi V.12ORCID,Robison Leslie L.5ORCID,Oeffinger Kevin C.7ORCID,Tonorezos Emily S.8ORCID

Affiliation:

1. Memorial Sloan Kettering Cancer Center, New York, New York. 1

2. Weill Cornell Medical College, New York, New York. 2

3. Johns Hopkins University Schools of Medicine and Public Health, Baltimore, Maryland. 3

4. Hunter College and The Graduate Center, City University of New York, New York, New York. 4

5. St. Jude Children’s Research Hospital, Memphis, Tennessee. 5

6. The Hospital for Sick Children, Toronto, Canada. 6

7. Duke Cancer Institute, Duke University, Durham, North Carolina. 7

8. National Cancer Institute, National Institutes of Health, Rockville, Maryland. 8

Abstract

Abstract Background: Obesity is prevalent in childhood cancer survivors and interacts with cancer treatments to potentiate risk for cardiovascular (CV) death. We tested a remote weight-loss intervention trial that was effective among adults with CV risk factors in a cohort of adult survivors of childhood acute lymphoblastic leukemia (ALL) with overweight/obesity. Methods: In this phase III efficacy trial, survivors of ALL enrolled in the Childhood Cancer Survivor Study with a body mass index ≥25 kg/m2 were randomized to a remotely delivered weight-loss intervention versus self-directed weight loss, stratified by history of cranial radiotherapy. The primary endpoint was the difference in weight loss at 24 months in an intent-to-treat analysis. Analyses were performed using linear mixed-effects models. Results: Among 358 survivors (59% female; median attained age: 37 years; IQR: 33–43 years), the baseline mean (SD) weight was 98.6 kg (24.0) for the intervention group (n = 181) and 94.9 kg (20.3) for controls (n = 177). Adherence to the intervention was poor; 15% of individuals in the intervention group completed 24/30 planned coaching calls. Weight at 24 months was available for 274 (77%) participants. After controlling for cranial radiotherapy, sex, race/ethnicity, and age, the mean (SE) change in weight from baseline to 24 months was −0.4 kg (0.8) for the intervention group and 0.2 kg (0.6) for control participants (P = 0.59). Conclusions: A remote weight-loss intervention that was successful among adults with CV conditions did not result in significant weight loss among adult survivors of childhood ALL. Impact: Future interventions in this population must be tailored to the unique needs of survivors to encourage engagement and adherence. See related In the Spotlight, p. 1147

Funder

National Cancer Institute

American Institute for Cancer Research

Meg Berte Owen Fund

American Lebanese-Syrian Associated Charities

Publisher

American Association for Cancer Research (AACR)

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