Seed Becoming Soil: A New Paradigm of the Ewing Sarcoma Tumor Microenvironment-Reference-Cited by-同舟云学术

Seed Becoming Soil: A New Paradigm of the Ewing Sarcoma Tumor Microenvironment

Published:2023-10-05 Issue:24 Volume:29 Page:5002-5004
ISSN:1078-0432
Container-title:Clinical Cancer Research
language:en
Short-container-title:

Author:

Kuo Christopher¹²^ORCID,Amatruda James F.¹²³^ORCID

Affiliation:

1. 1Cancer and Blood Disease Institute, Children's Hospital Los Angeles, Los Angeles, California.

2. 2Department of Pediatrics, Keck School of Medicine, University of Southern California, Los Angeles, California.

3. 3Department of Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California.

Abstract

SummaryCells in the tumor microenvironment, including cancer-associated fibroblasts (CAF), contribute to tumor growth and immune evasion. A recent study of Ewing sarcoma identified “CAF-like” tumor cells that mimic the protumorigenic features of CAFs. These findings highlight the role of cell plasticity in tumor growth.See related article by Wrenn et al., p. 5140

Funder

Coco Johnson Fellowship in Pediatric Sarcoma

A.P. Giannini Foundation

National Cancer Institute

St. Baldrick's Foundation

Publisher

American Association for Cancer Research (AACR)

Subject

Cancer Research,Oncology

Link

https://aacrjournals.org/clincancerres/article-pdf/doi/10.1158/1078-0432.CCR-23-2259/3371178/ccr-23-2259.pdf

Reference19 articles.

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3. Tumor microenvironment: sanctuary of the devil;Hui;Cancer Lett,2015

4. Tumors are unique organs defined by abnormal signaling and context;Radisky;Semin Cancer Biol,2001

5. Fibroblasts in cancer;Kalluri;Nat Rev Cancer,2006