PRESSING Need of Precision Care in HER2-Positive Colorectal Cancer: The ELEPHANT in the Room
Author:
Affiliation:
1. 1Department of Gastrointestinal Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas.
2. 2BC Cancer, University of British Columbia, Vancouver, British Columbia, Canada.
Abstract
Funder
National Cancer Institute
Publisher
American Association for Cancer Research (AACR)
Subject
Cancer Research,Oncology
Link
https://aacrjournals.org/clincancerres/article-pdf/doi/10.1158/1078-0432.CCR-23-2580/3382937/ccr-23-2580.pdf
Reference21 articles.
1. Negative hyper-selection of patients with HER2-positive and RAS wild-type metastatic colorectal cancer receiving dual HER2 blockade: the PRESSING-HER2 study;Randon;Clin Cancer Res,2024
2. Pertuzumab plus trastuzumab for HER2-amplified metastatic colorectal cancer (MyPathway): an updated report from a multicentre, open-label, phase 2a, multiple basket study;Meric-Bernstam;Lancet Oncol,2019
3. Dual-targeted therapy with trastuzumab and lapatinib in treatment-refractory, KRAS codon 12/13 wild-type, HER2-positive metastatic colorectal cancer (HERACLES): a proof-of-concept, multicentre, open-label, phase 2 trial;Sartore-Bianchi;Lancet Oncol,2016
4. Plasma HER2 (ERBB2) copy number predicts response to HER2-targeted therapy in metastatic colorectal cancer;Siravegna;Clin Cancer Res,2019
5. Circulating tumor DNA-guided treatment with pertuzumab plus trastuzumab for HER2-amplified metastatic colorectal cancer: a phase 2 trial;Nakamura;Nat Med,2021
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