Unveiling the Culprit: IL17 Signaling in the Pancreatic Epithelium Drives Tumorigenesis-Reference-Cited by-同舟云学术

Unveiling the Culprit: IL17 Signaling in the Pancreatic Epithelium Drives Tumorigenesis

Published:2024-07-11 Issue:9 Volume:12 Page:1130-1131
ISSN:2326-6066
Container-title:Cancer Immunology Research
language:en
Short-container-title:

Author:

Lee Kyoung Eun¹²^ORCID,Pasca di Magliano Marina²³⁴^ORCID

Affiliation:

1. Department of Pharmacology, University of Michigan, Ann Arbor, Michigan. 1

2. Rogel Cancer Center, University of Michigan, Ann Arbor, Michigan. 2

3. Department of Surgery, University of Michigan, Ann Arbor, Michigan. 3

4. Department of Cell and Developmental Biology, University of Michigan, Ann Arbor, Michigan. 4

Abstract

Abstract IL17 signaling promotes pancreatic cancer development, yet the cell compartment responsible for the protumorigenic function of IL17 has not been defined. In this article, Castro-Pando and colleagues demonstrate that IL17/IL17 receptor A signaling in the pancreatic epithelium is critical for pancreatic cancer initiation and for establishing immunosuppression, whereas its signaling in the immune compartment is dispensable. This work provides an important mechanistic insight on the role of IL17 signaling and identifies a potential new immune checkpoint as a target in pancreatic cancer. See related article by Castro-Pando et al., p. 1170

Publisher

American Association for Cancer Research (AACR)

Link

https://aacrjournals.org/cancerimmunolres/article-pdf/doi/10.1158/2326-6066.CIR-24-0479/3474107/cir-24-0479.pdf

Reference5 articles.

1. Pancreatic cancer: advances and challenges;Halbrook;Cell,2023

2. Oncogenic Kras activates a hematopoietic-to-epithelial IL-17 signaling axis in preinvasive pancreatic neoplasia;McAllister;Cancer Cell,2014

3. Pancreatic epithelial IL-17/IL-17RA signaling drives B7-H4 to promote tumorigenesis;Castro-Pando,2024

4. IL17A critically shapes the transcriptional program of fibroblasts in pancreatic cancer and switches on their protumorigenic functions;Mucciolo;Proc Natl Acad Sci U S A,2021

5. Gut epithelial Interleukin-17 receptor A signaling can modulate distant tumors growth through microbial regulation;Chandra;Cancer Cell,2024