Ocular Toxicity of Benzalkonium Chloride Homologs Compared with Their Mixtures

Author:

Okahara Akihiko1,Tanioka Hidetoshi1,Takada Koichi1,Kawazu Kouichi1

Affiliation:

1. Nara Research & Development Center, Santen Pharmaceutical Co., Ltd., 8916-16 Takayama-cho, Ikoma, Nara 630-0101, Japan

Publisher

Japanese Society of Toxicologic Pathology

Subject

Toxicology,Pathology and Forensic Medicine

Reference29 articles.

1. 1. Ammar DA, Noecker RJ, and Kahook MY. Effects of benzalkonium chloride- and polyquad-preserved combination glaucoma medications on cultured human ocular surface cells. Adv Ther. 28: 501–510. 2011.

2. 2. tiftein SP, Ahdoot M, Marcus E, and Asbell PA. Comparative toxicity of preservatives on immortalized corneal and conjunctival epithelial cells. J Ocul Pharmacol Ther. 25: 113–119. 2009.

3. 3. Li J, and Yan X. Toxicity of benzalkonium chloride on human corneal epithelial cells in vitro. Chin Ophthal Res. 26: 814–817. 2008.

4. 4. Tripathi BJ, Tripathi RC, and Kolli SP. Cytotoxicity of ophthalmic preservatives on human corneal epithelium. Lens Eye Toxic Res. 9: 361–375. 1992.

5. 5. Tripathi BJ, and Tripathi RC. Cytotoxic effects of benzalkonium chloride and chlorobutanol on human corneal epithelial cells in vitro. Lens Eye Toxic Res. 6: 395–403. 1989.

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