Protective effect of Aurelia aurita against free radicals and streptozotocin-induced diabetes

Author:

Talluri Mallikarjuna Rao,Ketha Alekhya,Battu Ganga Rao,Tadi Rajananda Swamy,Tatipamula Vinay BharadwajORCID

Abstract

<p class="Abstract">The present work was carried out to identify the anti-oxidant and anti-diabetic activities of Aurelia aurita. The chemical profiling analysis showed that it possess different biologically active secondary metabolites like phenols, alakoids, steroids etc. The methanolic extract showed different free radical scavenging activity as ascorbic acid with  IC<sub>50</sub> values 202, 205, 153 µg on DPPH, hydroxyl and superoxide free radicals. The extract significantly reduced the hyperglycemic conditions with percentage of reduction 18.7 ± 1.3 to 53.5 ±1.5 of streptozotocin-induced animals and the positive result of in-vitro aldose reductase enzyme inhibition with IC<sub>50</sub> value 163 µg suggests that A. aurita have potential to cure the diabetic complications.</p>

Publisher

Bangladesh Journals Online (JOL)

Subject

Pharmacology

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