Hypoalbuminemia in COVID-19: Molecular and Mechanistic Approach
-
Published:2023-06-06
Issue:1
Volume:2023
Page:1-11
-
ISSN:2816-8119
-
Container-title:Albus Scientia
-
language:
-
Short-container-title:Albus Scientia
Author:
Ali Afzal ,Sara Shahzaman ,Arwa Azam ,Usman Ghani ,Muhammad Babar Khawar ,Nimra Afzal ,Muhammad Idnan ,Ume Habiba ,Muhammad Abu Talha Safdar Hashmi ,Syeda Eisha Hamid ,Rimsha Naseem
Abstract
Hypoalbuminemia is a clinical feature of COVID-19 which is caused by a multitude of processes in COVID-19, including acute liver damage (ALI), oxidative burst, viral-albumin binding, dysregulated immunological responses, and viral genome interference in the host cell, all of which lead to organ failure and patient mortality. We used a mechanistic approach to discuss a number of potential molecular mechanisms that cause hypoalbuminemia, as well as some effective treatment methods. As this study employs molecular approaches to characterize hypoalbuminemia, this work is promising in molecular medicine and drug development.
Publisher
Albus Scientific Inc.
Reference111 articles.
1. Aloisio, E., Chibireva, M., Serafini, L., Pasqualetti, S., Falvella, F. S., Dolci, A., & Panteghini, M. (2020). A Comprehensive Appraisal of Laboratory Biochemistry Tests as Major Predictors of COVID-19 Severity. Archives of Pathology & Laboratory Medicine, 144(12), 1457–1464. https://doi.org/10.5858/arpa.2020-0389-SA 2. Amaan, H. N., Khawar, M. B., Abbasi, M. H., & Sheikh, N. (2020). Risk assessment in Pakistani health workers during COVID-19 pandemic. RADS Journal of Pharmacy and Pharmaceutical Sciences, 8(2), 126-128. https://doi.org/10.37962/jpps.v8i2.422 3. Bastug, A., Bodur, H., Erdogan, S., Gokcinar, D., Kazancioglu, S., Kosovali, B. D., Ozbay, B. O., Gok, G., Turan, I. O., Yilmaz, G., Gonen, C. C., & Yilmaz, F. M. (2020). Clinical and laboratory features of COVID-19: Predictors of severe prognosis. International Immunopharmacology, 88, 106950. https://doi.org/10.1016/j.intimp.2020.106950 4. Bi, X., Su, Z., Yan, H., Du, J., Wang, J., Chen, L., Peng, M., Chen, S., Shen, B., & Li, J. (2020). Prediction of severe illness due to COVID-19 based on an analysis of initial Fibrinogen to Albumin Ratio and Platelet count. Platelets, 31(5), 674–679. https://doi.org/10.1080/09537104.2020.1760230 5. Bonetti, G., Manelli, F., Patroni, A., Bettinardi, A., Borrelli, G., Fiordalisi, G., Marino, A., Menolfi, A., Saggini, S., Volpi, R., Anesi, A., & Lippi, G. (2020). Laboratory predictors of death from coronavirus disease 2019 (COVID-19) in the area of Valcamonica, Italy. Clinical Chemistry and Laboratory medicine, 58(7), 1100–1105. https://doi.org/10.1515/cclm-2020-0459
|
|