PREDICTION OF THE RISKS OF THE DEVELOPMENT OF COMORBIDITY OF CORONARY HEART DISEASE AND OBESITY IN THE BACKGROUND OF MILITARY ACTIONS-Reference-Cited by-同舟云学术

PREDICTION OF THE RISKS OF THE DEVELOPMENT OF COMORBIDITY OF CORONARY HEART DISEASE AND OBESITY IN THE BACKGROUND OF MILITARY ACTIONS

Published:2023 Issue:10 Volume:76 Page:2143-2149
ISSN:0043-5147
Container-title:Wiadomości Lekarskie
language:en
Short-container-title:Wiad Lek

Author:

Gridneva Olga V.¹,Kravchun Pavlo G.¹,Ryndina Natalia G.¹,Kadykova Olga I.¹

Affiliation:

1. KHARKIV NATIONAL MEDICAL UNIVERSITY, KHARKIV, UKRAINE

Abstract

The aim: Study of prognostic possibilities of batokine complexes (fibroblast growth factor (FGF-21) and vascular endothelial growth factor A (VEGF-A)) in determining the risks of developing coronary heart disease (CHD) and obesity (especially in case of their comorbidity). Materials and methods: 105 patients aged 25–85 were examined: 70 (main group) –with CHD on the background of obesity and 35 – with isolated CHD (comparison group). Results: Probable associations with increased risks of comorbidity of CHD and obesity were: increased systolic blood pressure (SBP) (OR = 0.844 [95.0% CI 0.735–0.970], p = 0.017), FGF-21 (OR = 1.701 [95.0 % CI 1.219–2.375], p = 0.002), VEGF-A (OR = 1.725 [95.0% CI 1.213–2.372], p = 0.005), low-density lipoprotein (LDL) (OR = 4.419 [95.0% CI 1.351–14.469], p = 0.014). Probable associations were also established for lesions of the left anterior descending artery (LADA) (OR = 1.117 [95.0% CI 0.987–1.263], p = 0.078), intermediate branch of the left coronary artery (IBLCA) (OR = 1.336 [95.0% CI 1.099–1.624], p = 0.004). Conclusions: The values of the characteristics of batokine metabolism (FGF-21 and VEGF-A levels) can be used as a significant predictor of the development of obesity in CHD. Increased levels of FGF-21 and VEGF-A in blood serum characterize a significant relationship with the development of such comorbidity, which indicates a significant influence of batokine complexes on the pathogenesis of comorbidity of CHD and obesity.

Publisher

ALUNA

Subject

General Medicine

Reference25 articles.

1. 1. Gheorghe A, Griffiths U, Murphy A et al. The economic burden of cardiovascular disease and hypertension in low- and middle-income countries: a systematic review. BMC Public Health. 2018;18:975. doi: 10.1186/s12889-018-5806-x.

2. 2. Dziuba OM., Pazynych LM, Sytenko OR, Kryvenko YeM. Shchodo pytannia hlobalnoho tiaharia khvorob v Ukraini [Regarding the issue of the global burden of diseases in Ukraine]. Visn. sotsialnoi hihiieny ta orhanizatsii okhorony zdorovia Ukrainy [Visn. of social hygiene and health care organizations of Ukraine]. 2017;2(72):8–13. doi: 10.11603/1681-2786.2017.2.8101. (In Ukrainian).

3. 3. Yuyun MF, Sliwa K, Kengne AP et al. Cardiovascular Diseases in Sub-Saharan Africa Compared to High-Income Countries: An Epidemiological Perspective. Glob Heart. 2020;12;15(1):15. doi: 10.5334/gh.403.

4. 4. GBD 2017 Causes of Death Collaborators. Global, regional, and national age-sex-specific mortality for 282 causes of death in 195 countries and territories, 1980–2017: a systematic analysis for the Global Burden of Disease Study 2017. Lancet. 2018;10;392(10159):1736–1788. doi: 10.1016/S0140-6736(18)32203-7.

5. 5. Shaposhnikov DI, Radomskyi OV. Analiz epidemiolohichnoi sytuatsii shchodo khvorob systemy krovoobihu v Ukraini ta Pakystani [Analysis of the epidemiological situation regarding diseases of the circulatory system in Ukraine and Pakistan]. Tezy dopovidei 75-yi Vseukrainskoi studentskoi naukovoi konferentsii «Medical students conference in Poltava» (MEDSCOP 2019), m. Poltava, 28–29 bereznia 2019 r. Poltava [Abstracts of reports of the 75th All-Ukrainian student scientific conference «Medical students’ conference in Poltava» (MEDSCOP 2019), Poltava, March 28-29, 2019, Poltava]. Poltava. 2019, р.107. (In Ukrainian).