Activity of chaperones in the endometrium in the presence of HIV

Abstract

The presence of human immunodeficiency virus (HIV) as a cause of acquired immunodeficiency remains a medical and social problem despite the success of antiretroviral therapy. Heat shock proteins (heat-shock proteins - HSP) are a family of proteins produced by cells in response to stressful conditions. The aim of the study was to determine the activity of heat shock proteins in the endometrium in the presence of HIV infection. Research groups were formed with 25 cases in each group: a group with HIV infection, a group with a combination of HIV infection and alcoholism, and a control group. An immunohistochemical study was conducted with monoclonal antibodies to HSP70 and HSP90. During the study, it was established that the presence of HIV infection and its combination with chronic alcoholism leads to the development of pathological processes in the endometrium (or in the endometrium) with signs of microcirculatory channel disturbances, sclerotic changes, and a tendency to endometrial atrophy. At the same time, there is a reliable activation of HSP70 and HSP90, which can be a sign of early non-plastic changes in the endometrium. Heat shock proteins are recognized by the immune system and cause further development of humoral and cellular immunity reactions. The level of heat shock proteins increases in the foci of inflammation, and they are also involved in the pathogenetic mechanisms of almost all diseases.The level of HSP70 expression increased from ([1.18±0.12] in the control group up to ([2.27±0.14] in the group of HIV infection and ([2.71±0.13] in the group of combination of chronic alcoholism and HIV infection. The level of HSP90 expression increased from ([0.73±0.09] in the control group up to ([2.13±0.13] in the group of combination of chronic alcoholism and HIV infection ([2.70±0.13] (p<0.05). Keywords: immune response, transformation, heat-shock proteins.