Lipid status and carotid intima-media thickness in patients with end-stage renal disease

Abstract

<p><strong>Aim</strong> <br />To assess morphological characteristics of carotid blood vessels in uremic patients before to the initiation of the dialysis treatment, and corelate data with various dialysis therapy modules.<br /><strong>Methods</strong> <br />The study included 30 patients with end-stage renal disease (ERDS) prior to commencing dialysis, 30 patients treated with<br />haemodialysis and 30 patients treated with continuous ambulatory peritoneal dialysis. The control group consisted of 15 subjects with normal kidney function (eGFR>60ml/min). Carotid intima-media thickness (CIMT), as well as lipid status values (cholesterol, triglycerides, low-density lipoprotein (LDL), high-density lipoprotein (HDL), apolipoprotein A, apolipoprotein B) were evaluated.<br /><strong>Results</strong> <br />The significant difference in CIMT was detected between the control and haemodialysis groups (p<0.001), and between<br />the control and the peritoneal dialysis group (p=0.004). In patients in the predialysis group, CIMT was influenced by cholesterol (p=0.013), HDL (p=0.044), LDL (p=0.001) and ApoB (p=0.042) values. A significant difference in CIMT was proved between the haemodialysis and predialysis group of patients (p<0.001). The only variable from the patient's lipometabolic profile significantly associated with the change in IMT in uremic patients was HDL. A<br />significant difference was found in the average value for systolic blood pressure (p<0.001) and diastolic blood pressure (p=0.018) in patients before starting the dialysis treatment compared to patients treated with other dialysis methods.<br /><strong>Conclusion</strong> <br />Patients on haemodialysis treatment had a significantly greater CIMT, which is in relation with a higher cardiovascular risk.</p>