Author:
Thomas John E.,Kang Seungho,Wyatt Charles J.,Kim Forest S.,Mangelsdorff A. David,Weigel Fred K.
Abstract
Glucose-6-phosphate dehydrogenase (G6PD) protects erythrocytes from oxidative stress and hemolysis; G6PD deficiency is the most prevalent enzymopathy. The United States military routinely performs tests to prevent exposing G6PD-deficient personnel to antimalarial drugs that might cause life-threatening hemolytic reactions. In addition, G6PD is a key determinant of vascular function, and its deficiency can lead to impaired nitric oxide production and greater vascular oxidant stress—precursors to atherosclerosis and cardiovascular disease. Using military medical records, we performed a retrospective, cross-sectional study to investigate whether deficient G6PD levels are associated with a higher prevalence of cardiovascular disease than are normal levels, and, if so, whether the relationship is independent of accepted cardiovascular risk factors.
We analyzed the medical records of 737 individuals who had deficient G6PD levels and 16,601 who had normal levels. Everyone had been screened at U.S. military medical centers from August 2004 through December 2007. We evaluated our dependent variable (composite cardiovascular disease) at the individual level, and performed binary logistic regression of our independent variable (G6PD status) and control variables (modifiable cardiovascular risk factors). The adjusted odds ratio of 1.396 (95% CI, 1.044–1.867; P <0.05) indicated that G6PD-deficient individuals have 39.6% greater odds of developing cardiovascular disease than do those with normal levels.
Early intervention may reduce the incidence of cardiovascular disease in military personnel and civilians who have deficient G6DP levels.
Publisher
Texas Heart Institute Journal
Subject
Cardiology and Cardiovascular Medicine
Reference25 articles.
1. Glucose-6-phosphate dehydrogenase deficiency;Luzzatto;Nathan and Oski's hematology of infancy and childhood,2009
2. Discovering the full spectrum of cardiovascular disease: Minority Health Summit 2003: report of the Basic Science Writing Group;Benjamin;Circulation,2005
3. Lifetime risks of cardiovascular disease;Berry;N Engl J Med,2012
4. Associations between red cell glucose-6-phosphate dehydrogenase variants and vascular diseases;Long;Am J Hum Genet,1967
5. Impact of glucose-6-phosphate dehydrogenase deficiency on the pathophysiology of cardiovascular disease;Hecker;Am J Physiol Heart Circ Physiol,2013
Cited by
34 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献