Emerging role for ERM proteins in cell adhesion and migration
Author:
Publisher
Informa UK Limited
Subject
Cell Biology,Cellular and Molecular Neuroscience
Link
http://www.tandfonline.com/doi/pdf/10.4161/cam.5.2.15081
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1. The switchable integrin adhesome
2. A gene family consisting of ezrin, radixin and moesin. Its specific localization at actin filament/plasma membrane association sites
3. Ezrin has a COOH-terminal actin-binding site that is conserved in the ezrin protein family.
4. Ezrin contains cytoskeleton and membrane binding domains accounting for its proposed role as a membrane-cytoskeletal linker.
5. Ezrin self-association involves binding of an N-terminal domain to a normally masked C-terminal domain that includes the F-actin binding site.
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