Molecular mechanism of allicin-induced apoptosis in human oral squamous cell carcinoma (OSCC)
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Published:2022-07-25
Issue:
Volume:
Page:33-39
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ISSN:2672-7277
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Container-title:Asia Pacific Journal of Molecular Biology and Biotechnology
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language:en
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Short-container-title:APJMBB
Author:
Hazwani Farrah1, Mohd Amin Indah1, Abdul Rahim Mohd Aizat1
Affiliation:
1. Faculty of Dentistry, UiTM Campus Sungai Buloh, Jalan Hospital, 47000 Sungai Buloh, Selangor, Malaysia
Abstract
90% - 95% of oral malignancies are reported to be contributed by oral squamous cell carcinoma (OSCC). Patients with oral cancer also have suffered from a stagnant survival rate of 50% for decades. With the advancement in technologies and medicine discovery, the standard solution for oral cancer is via chemotherapy and surgery. An alternative for the treatment is by incorporating a genotoxic drug, cisplatin. Unfortunately, cisplatin has been reported by many patients to give unpleasant effects such as nausea, vomiting, diarrhea and abdominal pain. Hence, a more reliable treatment needs to be unleashed. Allicin (diallylthiosulfinate) is well known for its antioxidant, antifungal, anti-inflammatory and antimicrobial purposes. Numerous studies have also reported the effectiveness of allicin as an anticancer agent against multiple cancer cell strains. With treatment of allicin in a dose-dependent manner, inhibition of carcinoma cells proliferation through a programmed cell death called apoptosis was considered favourable. Allicin induces apoptosis by activating cascades of caspases and caspase independent pathways as well as increasing p53 and Bax/Bcl2 expression. Allicin serves many potentials to fight off oral cancer carcinoma cells but there seems to be a limited amount of study in the oral cancer area. Therefore, this review article would like to highlight the reported studies on allicin in various cancer cell lines including oral cancer cells.
Funder
Ministry of Higher Education, Malaysia
Publisher
Malaysian Society for Molecular Biology and Biotechnology
Subject
Molecular Biology,Biotechnology
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