Affiliation:
1. Federal Research Centre “Komi Science Centre of the Ural Branch of the Russian Academy of Sciences”
2. FSBI “Zakusov Institute of Pharmacology”
Abstract
Aim. The potential distribution of the cardioelectric field on the body surface during the initial atrial activity and the sequence of depolarization of the atrial subepicardium in rats with experimentally induced pulmonary hypertension were compared. This work is devoted to non-invasive detection of arrhythmogenic foci of atria by using the cardioelectric field on the body surface during experimental pulmonary hypertension.Materials and methods. The method of cardioelectrochronotopography has been used to study the electric field of the heart on the body surface and the sequence of propagation of the excitation wave along the atrial epicardium in rats with experimentally induced pulmonary hypertension caused by a single injection of monocrotaline (60 mg / kg, four weeks after drug administration).Results. Pulmonary hypertension causes the appearance of an additional focus of initial excitation in the area of the pulmonary vein lacunae, which leads to an increase in the heterogeneity of the propagation of the excitation wave along the atrial epicardium. The appearance of the additional excitation focus in the mouths of the pulmonary veins in the left atrium changes the picture of the sequence of depolarization of the atrial epicardium. The heterogeneity of the propagation of the excitation wave along the atrial epicardium is reflected in a different arrangement of zones of positive and negative cardioelectric potentials on the body surface before and during the P-wave in comparison with the initial state.Conclusion. Induced pulmonary hypertension contributes to the appearance of an additional focus of initial excitation in the area of the sleeves of the pulmonary veins of the left atrium in rats. This leads to an increase in the heterogeneity of the propagation of the excitation wave along the atrial epicardium. This is also reflected in the change in the arrangement of the zones of positive and negative cardioelectric potentials on the body surface before and during the P-wave in comparison with the initial state.
Publisher
Institute of Cardio Technics - INCART
Subject
Marketing,Organizational Behavior and Human Resource Management,Strategy and Management,Drug Discovery,Pharmaceutical Science,Pharmacology
Reference45 articles.
1. Zoni-Berisso M, Lercari F, Carazza T, et al. Epidemiology of atrial fibrillation: European perspective. Clin Epidemiol. 2014;6: 213-20. DOI:10.2147/CLEP.S47385.
2. McManus DD, Rienstra M, Benjamin EJ. An update on the prognosis of patients with atrial fibrillation. Circulation. 2012;126(10): e143-6. DOI:10.1161/CIRCULATIONAHA.112.129759.
3. Ball J, Carrington MJ, McMurray JJ, et al. Atrial fibrillation: profile and burden of an evolving epidemic in the 21st century. Int J Cardiol. 2013;167(5): 1807-24. DOI:10.1016/j.ijcard.2012.12.093.
4. Oldgren J, Healey JS, Ezekowitz M, et al. Variations in cause and management of atrial fibrillation in a prospective registry of 15,400 emergency department patients in 46 countries. The RE-LY Atrial fibrillation registry. Circulation. 2014;129(15): 1568-76. DOI:10.1161/CIRCULATIONAHA.113.005451.
5. Pathak R, Lau DH, Mahajan R, et al. Structural and functional remodeling of the left atrium: clinical and therapeutic implications for atrial fibrillation. J Atr Fibrillation. 2013;6(4): 986. DOI:10.4022/jafib.986.
Cited by
4 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献