Evaluation of Inflammatory Markers in Patients with Fibromyalgia Syndrome in King Abdulaziz University Hospital (KAUH) in Jeddah, Saudi Arabia: A Cross-Sectional Study

Abstract

Objectives: The goal of this study was to examine various markers in patients with FMS, including the neutrophil/lymphocyte ratio (NLR),platelet/lymphocyte ratio (PLR), platelet distribution width (PDW), and mean platelet volume (MPV). Methods: This was a cross-sectional, retrospective study conducted at King Abdulaziz University Hospital (KAUH) in Jeddah, Saudi Arabia,involving the examination of inflammatory markers, such as PDW, NLR, and MPV. The results were evaluated with IBM SPSS version 25, and a P-value of <0.05 was used to reject the null hypothesis. Results: In total, 396 participants were included in this study: 235 in the FMS group and 161 in the control group. MPV, PDW and NLR values are 10.31 ± 1.6 fL, 124.57 ± 70.0, 2.30 ± 3.2, respectively. The PDW in the control group (12.47 ± 2.5) was significantly higher than that in the FMS group (11.84 ± 2.4) (P = 0.003). Erythrocyte sedimentation rate and Vitamin D levels (P = 0.001) were significantly higher in the control group than in the FMS group, with values of 31.71 and 24.2 and 75.60 and 39.4, respectively. No significant differences were found in MPV and NLR values between the FMS and control groups. Conclusion: The findings in this study suggest that PDW and PLR are important inflammatory markers that may be beneficial in FMSdiagnosis.