Trastornos de la coagulación: factor V Leiden, panorama biológico, clínico y epidemiológico

Author:

Hernández-Girón Carlos1ORCID,Cabrales-Arreola Jorge Luis1ORCID

Affiliation:

1. Instituto Nacional de Salud Pública INSP). Centro de Investigaciones en Salud Poblacional. Cuernavaca, Mor. México

Abstract

The coagulation system always keeps the blood in a fluid state and is therefore incessantly active throughout life. However, the moment an injury to the vascular system occurs, the coagulation system immediately rotates 180° and transforms the blood into a perfectly localized solid body, which we call a clot. This process, by which a clot forms, is known as hemostasis, which is one of the components of the coagulation system. The importance of the Leiden mutation of factor V is based on the following: coagulation factor V is a protein that is synthesized in the liver and the gene that encodes it is located in region 23 of the long arm of chromosome 1, this factor circulates in peripheral blood inactively until it interacts with activated factor X forming a complex that converts factor II (prothrombin) into thrombin, which will have its action on fibrinogen turning it into fibrin. The regulation of activated factor V is given by the activity of activated protein C, when factor V has a mutation (named Leiden) that is caused by the exchange of an adenine for a guanine in the nucleotide 1691 of factor V (G1691A), which causes arginine to be replaced by a glutamine in the 506 residue of the factor V protein, the resulting protein is an abnormal factor V, which cannot be inactivated by activated protein C, so factor V remains activated and cannot prevent the clotting process from stopping. In our country (considering several conditions) it has been described in various publications of Mexican researchers that Leiden mutations of factor V and G20210A of prothrombin are not frequent, as they are in European countries. Keywords: Thrombophilia; factor V Leiden; coagulation disorders; Mexico

Publisher

Universidad Nacional Autonoma de Mexico

Reference26 articles.

1. 1. Majluf-Cruz A, Trombofilia. Gac Med Mex. 2017;153(4): 427-429. doi:10.24875/GMM.M17000013

2. 2. Parra-Ortega I, López-Valladares KE, Angeles-Floriano T, Moreno-González AM, López-Martínez B. La existencia de las mutaciones Leiden del factor V y G2021A de la protrombina es infrecuente en pacientes pediátricos mexicanos con hemofilia A grave. Rev Hematol Mex. 2019;20(3):198-203.

3. 3. World Federation Hemophilia (WFH). [Consultado 10 abril, 2022]. Disponible en: http://tinyurl.com/22yhsz2c

4. 4. Aguirre HD, Posada A. Deficiencia congénita del factor V. 2014;28(2):247-252. Recuperado de: https://www.redalyc. org/articulo.oa?id=261132654009

5. 5. Gómez Baute R, Guerra Alfonso T, Dita Salabert L, Fernández Águila JD, Cabrera Zamora M. Teoría celular de la coagulación: de las cascadas a las membranas celulares. Medisur [Internet]. 2011 Abr [citado 2022 Nov 02];9(2):146- 155. Disponible en: http://tinyurl.com/2blm3d9y

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3