Kinetic Study of Natural Anticancer Drug (Zerumbone) Release from Zeolite Y-Gelatin Hybrid for Oral Controlled Delivery-Reference-Cited by-同舟云学术

Kinetic Study of Natural Anticancer Drug (Zerumbone) Release from Zeolite Y-Gelatin Hybrid for Oral Controlled Delivery

Published:2024-01-07 Issue:SI17 Volume:9 Page:393-398
ISSN:2398-4287
Container-title:Environment-Behaviour Proceedings Journal
language:
Short-container-title:E-BPJ

Author:

Ramli Rosmamuhamadani,Salleh Norashikin,Mahat Mohd Muzamir,M Yahaya Sabrina

Abstract

A hybrid of zeolite Y-gelatin film as an oral dosage form for the natural anticancer drug was achieved by homogenously incorporating the drug-loaded zeolite Y into the gelatin solution. Drug ability was analyzed using computational and experimental approaches, drug encapsulation efficiency via the BET method, and possible interactions by FTIR analyses. Zerumbone released was done in both pH 1.2 and pH 7.4 mimicking the human gastrointestinal tract conditions for 24 hrs and subjected to kinetics study via suitable mathematical models to determine what governs the drug release with the results indicating that a sustained delivery of once-daily oral dosage form could be achieved.

Publisher

e-IPH Ltd.

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