A Surprising Role for the Sch9 Protein Kinase in Chromosome Segregation in Candida albicans-Reference-Cited by-同舟云学术

A Surprising Role for the Sch9 Protein Kinase in Chromosome Segregation in Candida albicans

Published:2015-01-15 Issue:3 Volume:199 Page:671-674
ISSN:1943-2631
Container-title:Genetics
language:en
Short-container-title:

Author:

Varshney Neha¹¹,Schaekel Alida²³¹,Singha Rima¹,Chakraborty Tanmoy¹¹,van Wijlick Lasse²³,Ernst Joachim F²³,Sanyal Kaustuv¹

Affiliation:

1. Molecular Mycology Laboratory, Jawaharlal Nehru Centre for Advanced Scientific Research, Jakkur, Bangalore 560064, India

2. Department Biologie, Molekulare Mykologie, Heinrich-Heine-Universität, Düsseldorf, Germany

3. Manchot Graduate School Molecules of Infection, Heinrich-Heine-Universität, Düsseldorf 40225, Germany

Abstract

Abstract The AGC kinase Sch9 regulates filamentation in Candida albicans. Here, we show that Sch9 binding is most enriched at the centromeres in C. albicans, but not in Saccharomyces cerevisiae. Deletion of CaSch9 leads to a 150- to 750-fold increase in chromosome loss. Thus, we report a previously unknown role of Sch9 in chromosome segregation.

Publisher

Oxford University Press (OUP)

Subject

Genetics

Link

https://academic.oup.com/genetics/article-pdf/199/3/671/42132177/genetics0671.pdf

Reference21 articles.

1. Formation of functional centromeric chromatin is specified epigenetically in Candida albicans.;Baum;Proc. Natl. Acad. Sci. USA,2006

2. Regulation of longevity and stress resistance by Sch9 in yeast.;Fabrizio;Science,2001

3. Efficient and rapid identification of Candida albicans allelic status using SNP-RFLP.;Forche;FEMS Yeast Res.,2009

4. The IML3/MCM19 gene of Saccharomyces cerevisiae is required for a kinetochore-related process during chromosome segregation.;Ghosh;Mol. Genet. Genomics,2001

5. Target specificity of the Candida albicans Efg1 regulator.;Lassak;Mol. Microbiol.,2011

Cited by 10 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Evolutionary diversity of the control of the azole response by Tra1 across yeast species;G3: Genes, Genomes, Genetics;2023-10-27

2. TOR1 dysfunction promotes phenotypic diversity in the asexual fungusCandida albicans;2023-05-12

3. Deep Learning in Phosphoproteomics: Methods and Application in Cancer Drug Discovery;Proteomes;2023-05-02

4. Spatial inter-centromeric interactions facilitated the emergence of evolutionary new centromeres;eLife;2020-05-29

5. Yeast Engineering for New Antifungal Compounds: A Contextualized Overview;Fungal Biology;2020