1. Banting and Best Department of Medical Research , Department of Medical Genetics and Microbiology, University of Toronto, Toronto, Ontario M5S 1A8, Canada
2. Terrence Donnelly Centre for Cellular and Biomolecular Research , University of Toronto, Toronto, Ontario M5S 3E1, Canada and
3. Department of Biochemistry , University of Toronto, Toronto, Ontario M5S 1A8, Canada