Combination Therapy of Choline Alfoscerate With Ginkgo biloba Monotherapy in Age-Related Hearing Loss: Effects and Outcomes

Abstract

Background and Objectives: <i>Ginkgo biloba</i> and choline alfoscerate are used as adjuvant treatment for presbycusis, but studies on how the monotherapy differs from the combination therapy are lacking. Therefore, this study aimed to compare the audiologic outcomes between <i>Ginkgo biloba</i> monotherapy and <i>Ginkgo biloba</i> and choline alfoscerate combination therapy.Subjects and Methods: The study groups are divided into three: negative control, monotherapy, and combination therapy groups. All groups’ pure tone audiometry was measured by dividing the study period into Initial, 3-6, 6-9, 9-12, 12-15 months, and checked whether differences between groups were present.Results: The combination therapy showed less gradient gap than the monotherapy, indicating less hearing loss rate than the monotherapy. Based on the Kaplan–Meier curve, the combination therapy showed better results in terms of survival time of hearing.Conclusions: As a pharmacological treatment for presbycusis, combination therapy shows better results than monotherapy.