An adaptive platform trial for evaluating treatments in patients with life‐threatening hemorrhage from traumatic injuries: Rationale and proposal

Author:

Tolles Juliana123,Beiling Marissa4,Schreiber Martin A.4,Del Junco Deborah J.56,McMullan Jason T.6,Guyette Francis X.7,Wang Henry8,Jansen Jan O.910ORCID,Meurer William J.31112,Mainali Shraddha13,Yadav Kabir12ORCID,Lewis Roger J.123

Affiliation:

1. Department of Emergency Medicine Harbor‐UCLA Medical Center Torrance California USA

2. Department of Emergency Medicine David Geffen School of Medicine at UCLA Los Angeles California USA

3. Berry Consultants, LLC Austin Texas USA

4. Division of Trauma, Critical Care & Acute Care Surgery, Department of Surgery Oregon Health & Science University Portland Oregon USA

5. Joint Trauma System, Defense Health Agency Joint Base San Antonio Fort Sam Houston San Antonio Texas USA

6. Department of Emergency Medicine University of Cincinnati College of Medicine Cincinnati Ohio USA

7. Department of Emergency Medicine University of Pittsburgh Pittsburgh Pennsylvania USA

8. Department of Emergency Medicine The Ohio State University Columbus Ohio USA

9. Center for Injury Science University of Alabama at Birmingham Birmingham Alabama USA

10. Division of Trauma & Acute Care Surgery, Department of Surgery University of Alabama at Birmingham Birmingham Alabama USA

11. Department of Emergency Medicine University of Michigan Ann Arbor Michigan USA

12. Department of Neurology University of Michigan Ann Arbor Michigan USA

13. Department of Neurology Virginia Commonwealth University Richmond Virginia USA

Publisher

Wiley

Subject

Hematology,Immunology,Immunology and Allergy

Reference46 articles.

1. National Center for Health Statistics Centers for Disease Control and Prevention.Leading Causes of Death and Numbers of Deaths by Age: United States 1980 and 2018. Available athttp://www.cdc.gov/nchs/hus/contents2019.htm#Table-007accessed December 1 2021.

2. ICU Management of Trauma Patients

3. Prehospital Trauma Triage Decision-making: A Model of What Happens between the 9-1-1 Call and the Hospital

4. Diversity in clinical management and protocols for the treatment of major bleeding trauma patients across European level I Trauma Centres

5. Zero preventable deaths after traumatic injury

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