Drug reaction with eosinophilia and systemic symptoms in a paediatric population: Interest of skin tests

Abstract

AbstractBackgroundDrug reaction with eosinophilia and systemic symptoms (DRESS) is a severe adverse drug reaction. It is uncommon in the paediatric population and can be difficult to diagnose as its initial symptoms may mimic a viral infection.ObjectiveTo analyse the features of paediatric DRESS and to evaluate the interest of skin tests in identifying the causative drugs.MethodsIt is a retrospective analysis (2004–2021) of DRESS cases diagnosed in paediatric patients. The DRESS diagnosis was defined using the RegiSCAR scoring. The skin tests were performed according to the ENDA recommendations.ResultsWe included 19 cases of DRESS occurred in 18 patients. Common clinical symptoms were exanthema and fever in 94.7% of cases each. The most commonly affected organ was the liver (84.2%). Among the implicated drugs, 16 were tested and skin tests were positive in 75%. To assess cross‐reactivity and co‐sensitization, skin tests with related and/or co‐administered drugs were performed in eight patients. Among them, only one child had positive results.ConclusionEarly diagnosis of DRESS and discontinuation of the incriminated drug might reduce the incidence of mortality in the paediatric population. Skin tests could be a safe and useful tool to identify the causative drug and assess cross‐reactivity.