Conservative vs liberal fluid therapy in septic shock (CLASSIC) trial—Protocol and statistical analysis plan

Author:

Meyhoff Tine Sylvest12ORCID,Hjortrup Peter Buhl1,Møller Morten Hylander12ORCID,Wetterslev Jørn23,Lange Theis4,Kjær Maj‐Brit Nørregaard12ORCID,Jonsson Andreas Bender1ORCID,Hjortsø Carl Johan Steensen1ORCID,Cronhjort Maria5,Laake Jon Henrik6ORCID,Jakob Stephan M.7,Nalos Marek8,Pettilä Ville9ORCID,Horst Iwan10ORCID,Ostermann Marlies11,Mouncey Paul12,Rowan Kathy12,Cecconi Maurizio13,Ferrer Ricard14,Malbrain Manu L. N. G.1516,Ahlstedt Christian17,Hoffmann Søren18,Bestle Morten Heiberg1920,Nebrich Lars21,Russell Lene2223ORCID,Vang Marianne24,Rasmussen Michael Lindhardt25,Sølling Christoffer26,Rasmussen Bodil Steen27,Brøchner Anne Craveiro28,Perner Anders12ORCID

Affiliation:

1. Department of Intensive Care Copenhagen University Hospital, Rigshospitalet Copenhagen Denmark

2. Centre for Research in Intensive Care (CRIC) Copenhagen Denmark

3. Copenhagen Trial Unit, Centre for Clinical Intervention Research Copenhagen University Hospital, Rigshospitalet Copenhagen Denmark

4. Department of Public Health, Section of Biostatistics University of Copenhagen Copenhagen Denmark

5. Department of Clinical Science and Education, Section of Anaesthesia and Intensive Care Karolinska Institutet, Södersjukhuset Stockholm Sweden

6. Department of Anaesthesiology, Division of Emergencies and Critical Care Rikshospitalet, Oslo University Hospital Oslo Norway

7. Department of Intensive Care Medicine University Hospital Bern (Inselspital), University of Bern Bern Switzerland

8. Medical Intensive Care Unit Interni klinika, Fakultni Nemocnice Plzen Czech Republic

9. Division of Intensive Care Medicine, Department of Anaesthesiology, Intensive Care and Pain Medicine University of Helsinki and Helsinki University Hospital Helsinki Finland

10. Department of Intensive Care University Medical Centre Groningen Groningen The Netherlands

11. Department of Intensive Care Guy’s and St Thomas’ Hospital London UK

12. Intensive Care National Audit & Research Centre (ICNARC) London UK

13. Department of Intensive Care Medicine Humanitas Research Hospital Milan Italy

14. Department of Intensive Care Hospital Vall d'Hebron Barcelona Spain

15. Department of Intensive Care Medicine University Hospital Brussels (UZB) Jette Belgium

16. Faculty of Medicine and Pharmacy Vrije Universiteit Brussel (VUB) Brussels Belgium

17. Department of Perioperative Medicine and Intensive Care Karolinska University Hospital Huddinge Stockholm Sweden

18. Department of Anaesthesia and Intensive Care Copenhagen University Hospital, Bispebjerg Copenhagen Denmark

19. Department of Anaesthesia and Intensive Care Nordsjællands Hospital, University Hospital of Copenhagen Hillerød Denmark

20. Department of Clinical Medicine University of Copenhagen Copenhagen Denmark

21. Department of Anaesthesia and Intensive Care Zealand University Hospital Køge Denmark

22. Department of Anaesthesia and Intensive Care Zealand University Hospital Roskilde Denmark

23. Copenhagen Academy for Medical Education and Simulation, Rigshospitalet Copenhagen Denmark

24. Department of Anaesthesia and Intensive Care Randers Hospital Randers Denmark

25. Department of Anaesthesia and Intensive Care Herning Hospital Herning Denmark

26. Department of Anaesthesia and Intensive Care Viborg Hospital Viborg Denmark

27. Department of Anaesthesia and Intensive Care Aalborg University Hospital Aalborg Denmark

28. Department of Anaesthesia and Intensive Care Lillebælt Hospital Kolding Denmark

Publisher

Wiley

Subject

Anesthesiology and Pain Medicine,General Medicine

Cited by 37 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. Fluid Accumulation and Deresuscitation;Rational Use of Intravenous Fluids in Critically Ill Patients;2023-11-30

2. Fluid Management in Intra-abdominal Hypertension;Rational Use of Intravenous Fluids in Critically Ill Patients;2023-11-30

3. Albumin use in patients with septic shock—Post‐hoc analyses of an international randomised fluid trial;Acta Anaesthesiologica Scandinavica;2023-11-17

4. Restrictive versus standard IV fluid therapy in adult ICU patients with septic shock—Bayesian analyses of the CLASSIC trial;Acta Anaesthesiologica Scandinavica;2023-10-23

5. Long-term effects of restriction of intravenous fluid in adult ICU patients with septic shock;Intensive Care Medicine;2023-06-18

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