Platelet collagen receptor Glycoprotein VI-dimer recognizes fibrinogen and fibrin through their D-domains, contributing to platelet adhesion and activation during thrombus formation
Author:
Affiliation:
1. Department of Clinical Neurosciences; University of Cambridge; Cambridge UK
2. Department of Biochemistry; University of Cambridge; Cambridge UK
Funder
British Heart Foundation
Publisher
Wiley
Subject
Hematology
Link
http://onlinelibrary.wiley.com/wol1/doi/10.1111/jth.13919/fullpdf
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3. Glycoprotein (GP) VI dimer as a major collagen-binding site of native platelets: direct evidence obtained with dimeric GPVI-specific Fabs;Jung;J Thromb Haemost,2009
4. Constitutive dimerization of glycoprotein VI (GPVI) in resting platelets is essential for binding to collagen and activation in flowing blood;Jung;J Biol Chem,2012
5. Structural basis for the platelet-collagen interaction: the smallest motif within collagen that recognizes and activates platelet Glycoprotein VI contains two glycine-proline-hydroxyproline triplets;Smethurst;J Biol Chem,2007
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