Sunitinib in metastatic renal cell carcinoma: An ethnic Asian subpopulation analysis for safety and efficacy

Author:

Lee Se-Hoon1,Bang Yung-Jue1,Mainwaring Paul2,Ng Christina3,Chang John W-C4,Kwong Philip5,Li Rubi K6,Sriuranpong Virote7,Toh Chee-Keong8,Yuan Jinyu9,Pitman Lowenthal Susan9,Chung Hyun C10

Affiliation:

1. Department of Internal Medicine; Seoul National University Hospital and Cancer Research Institute; Seoul National University College of Medicine; Seoul South Korea

2. Medical Oncology; Mater Adult Hospital; South Brisbane Queensland Australia

3. Medical Oncology, Department of Medicine; University Malaya Medical Centre; Kuala Lumpur Malaysia

4. Division of Hematology-Oncology, Department of Internal Medicine; Chang Gung Memorial Hospital; Chang Gung University College of Medicine; Taoyuan Taiwan

5. Department of Clinical Oncology; Queen Mary Hospital; Hong Kong China

6. Cancer Institute; St Luke's Medical Center; Quezon City Philippines

7. Medical Oncology Unit, Department of Medicine, Faculty of Medicine; Chulalongkorn University; Bangkok Thailand

8. Department of Medical Oncology; National Cancer Centre; Singapore

9. Pfizer Oncology; New York New York USA

10. Yonsei Cancer Center; Yonsei University College of Medicine; Yonsei University Health System; Seoul South Korea

Publisher

Wiley

Subject

Oncology,General Medicine

Reference23 articles.

1. SU11248 inhibits KIT and platelet-derived growth factor receptor beta in preclinical models of human small cell lung cancer;Abrams;Mol Cancer Ther,2003

2. In vivo antitumor activity of SU11248, a novel tyrosine kinase inhibitor targeting vascular endothelial growth factor and platelet-derived growth factor receptors: determination of a pharmacokinetic/pharmacodynamic relationship;Mendel;Clin Cancer Res,2003

3. SU11248 is a novel FLT3 tyrosine kinase inhibitor with potent activity in vitro and in vivo;O'Farrell;Blood,2003

4. Sunitinib versus interferon alfa in metastatic renal-cell carcinoma;Motzer;N Engl J Med,2007

5. Overall survival and updated results for sunitinib compared with interferon alpha in patients with metastatic renal cell carcinoma;Motzer;J Clin Oncol,2009

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