Hepatitis C: a possible etiology for cryoglobulinaemia type II-Reference-Cited by-同舟云学术

Hepatitis C: a possible etiology for cryoglobulinaemia type II

Published:1992-09 Issue:3 Volume:89 Page:419-422
ISSN:0009-9104
Container-title:Clinical and Experimental Immunology
language:en
Short-container-title:

Author:

PECHÈRE-BERTSCHI A¹,PERRIN L¹,de SAUSSURE P¹,WIDMANN J J²,GIOSTRA E¹,SCHIFFERLI J A¹

Affiliation:

1. Department of Medicine, Hôpital Cantonal Universitaire, Geneva, Switzerland

2. Department of Pathology, Hôpital Cantonal Universitaire, Geneva, Switzerland

Abstract

SUMMARY Out of 15 successive patients with mixed essential cryoglobulinaemia type II (monoclonal IgM kappa /IgG), 13 had serological evidence for hepatitis C infection as shown by specific enzyme immunoassays and immunoblot. RNA was purified from the serum of seven patients and hepatitis C sequences were identified in five following reverse transcription and DNA amplification. The liver histology showed chronic active hepatitis with or without cirrhosis in the 12 patients with hepatitis C who had a liver biopsy. The two patients without serological evidence of hepatitis C suffered from haematological malignancies. Hepatitis C may be a major etiological agent of cryoglobulinaemia type II.

Publisher

Oxford University Press (OUP)

Subject

Immunology,Immunology and Allergy

Link

https://academic.oup.com/cei/article-pdf/89/3/419/42212451/j.1365-2249.1992.tb06973.x.pdf

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