Affiliation:
1. Department of Pediatrics The First Affiliated Hospital of Ningbo University Ningbo Zhejiang China
2. Department of Pediatric Respiratory Medicine The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University Wenzhou Zhejiang China
3. Department of Pediatrics The Ningbo Women and Children's Hospital Ningbo China
4. College of Laboratory Medicine and Life Science Wenzhou Medical University Wenzhou Zhejiang China
Abstract
AbstractIntroductionAsthma and bronchiolitis in children are considered common clinical problems associated with gut microbiota. However, the exact relationship between gut microbiota and the above‐mentioned diseases remains unclear. Here, we discussed recent advances in understanding the potential mechanism underlying immune regulation of gut microbiota on asthma and bronchiolitis in children as well as the role of the gut–lung axis.MethodsWe retrieved and assessed all relevant original articles related to gut microbiota, airway inflammation‐induced wheezing in children, and gut–lung axis studies from databases that have been published so far, including PubMed/MEDLINE, Scopus, Google Scholar, China National Knowledge Infrastructure (CNKI) and the Wanfang Database.ResultsThe infant period is critical for the development of gut microbiota, which can be influenced by gestational age, delivery mode, antibiotic exposure and feeding mode. The gut microbiota in children with asthma and bronchiolitis is significantly distinct from those in healthy subjects. Gut microbiota dysbiosis is implicated in asthma and bronchiolitis in children. The presence of intestinal disturbances in lung diseases highlights the importance of the gut–lung axis.ConclusionGut microbiota dysbiosis potentially increases the risk of asthma and bronchiolitis in children. Moreover, a deeper understanding of the gut–lung axis with regard to the gut microbiota of children with respiratory diseases could contribute to clinical practice for pulmonary diseases.
Funder
National Natural Science Foundation of China
Subject
Genetics (clinical),Pulmonary and Respiratory Medicine,Immunology and Allergy
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