Development of the PSYCHS: Positive SYmptoms and Diagnostic Criteria for the CAARMS Harmonized with the SIPS

Author:

Woods Scott W.12ORCID,Parker Sophie34,Kerr Melissa J.56,Walsh Barbara C.12,Wijtenburg S. Andrea7,Prunier Nicholas8,Nunez Angela R.12,Buccilli Kate56,Mourgues‐Codern Catalina12,Brummitt Kali9,Kinney Kyle S.10,Trankler Carli11,Szacilo Julia12,Colton Beau‐Luke3,Ali Munaza12,Haidar Anastasia8,Billah Tashrif8,Huynh Kevin56,Ahmed Uzair56,Adery Laura L.13ORCID,Marcy Patricia J.14,Allott Kelly56ORCID,Amminger Paul56,Arango Celso15,Broome Matthew R.1617,Cadenhead Kristin S.18,Chen Eric Y. H.19ORCID,Choi Jimmy20,Conus Philippe21,Cornblatt Barbara A.1422,Glenthøj Louise Birkedal23ORCID,Horton Leslie E.24,Kambeitz Joseph25,Kapur Tina26,Keshavan Matcheri S.27,Koutsouleris Nikolaos282930,Langbein Kerstin31,Lavoie Suzie56ORCID,Diaz‐Caneja Covadonga Martinez15ORCID,Mathalon Daniel H.3233,Mittal Vijay A.34,Nordentoft Merete3536,Pasternak Ofer2637,Pearlson Godfrey D.120,Gaspar Pablo A.38ORCID,Shah Jai L.3940,Smesny Stefan31,Stone William S.27,Strauss Gregory P.41ORCID,Wang Jijun42,Corcoran Cheryl M.43,Perkins Diana O.44,Schiffman Jason45,Perez Jesus1246,Mamah Daniel11,Ellman Lauren M.10,Powers Albert R.12,Coleman Michael J.8,Anticevic Alan12,Fusar‐Poli Paolo4748ORCID,Kane John M.1422,Kahn Rene S.43,McGorry Patrick D.56,Bearden Carrie E.13,Shenton Martha E.83749ORCID,Nelson Barnaby56,Calkins Monica E.50ORCID,Hendricks Larry56,Bouix Sylvain851,Addington Jean9ORCID,McGlashan Thomas H.12,Yung Alison R.34552,

Affiliation:

1. Department of Psychiatry Yale University School of Medicine New Haven Connecticut USA

2. Connecticut Mental Health Center New Haven Connecticut USA

3. Division of Psychology and Mental Health, School of Health Sciences University of Manchester Manchester UK

4. Youth Mental Health Research Unit Greater Manchester Mental Health NHS Foundation Trust Manchester UK

5. Orygen Parkville Victoria Australia

6. Centre for Youth Mental Health The University of Melbourne Parkville Victoria Australia

7. Division of Translational Research National Institute of Mental Health Bethesda Maryland USA

8. Department of Psychiatry Brigham and Women's Hospital and Harvard Medical School Boston Massachusetts USA

9. Department of Psychiatry Hotchkiss Brain Institute, University of Calgary Calgary Alberta Canada

10. Department of Psychology & Neuroscience Temple University Philadelphia Pennsylvania USA

11. Department of Psychiatry Washington University School of Medicine St. Louis Missouri USA

12. CAMEO, Early Intervention in Psychosis Service Cambridgeshire and Peterborough NHS Foundation Trust Cambridge UK

13. Departments of Psychiatry and Biobehavioral Sciences & Psychology Semel Institute for Neuroscience and Human Behavior, University of California Los Angeles California USA

14. Feinstein Institute for Medical Research Manhasset New York USA

15. Department of Child and Adolescent Psychiatry Institute of Psychiatry and Mental Health, Hospital General Universitario Gregorio Marañón, Instituto de Investigación Sanitaria Gregorio Marañón (IiSGM), CIBERSAM, ISCIII, School of Medicine, Universidad Complutense Madrid Spain

16. Institute for Mental Health, School of Psychology University of Birmingham Birmingham UK

17. Birmingham Women's and Children's NHS Foundation Trust Birmingham UK

18. Department of Psychiatry University of California San Diego California USA

19. Department of Psychiatry University of Hong Kong Pok Fu Lam Hong Kong

20. Olin Neuropsychiatry Research Center Hartford HealthCare Behavioral Health Network Hartford Connecticut USA

21. Chef de Service Service de Psychiatrie Générale Dép. de Psychiatrie CHUV Lausanne Lausanne Switzerland

22. Department of Psychiatry Donald and Barbara Zucker School of Medicine Hempstead New York USA

23. Copenhagen Research Centre for Mental Health, Mental Health Copenhagen University of Copenhagen Copenhagen Denmark

24. Department of Psychiatry University of Pittsburgh School of Medicine Pittsburgh Pennsylvania USA

25. Faculty of Medicine and University Hospital of Cologne University of Cologne Cologne Germany

26. Brigham and Women's Hospital, Harvard Medical School Boston Massachusetts USA

27. Beth Israel Deaconess Medical Center Harvard Medical School Boston Massachusetts USA

28. Department of Psychiatry and Psychotherapy Ludwig Maximilian University Munich Munich Germany

29. Department of Psychiatry and Psychotherapy King's College London London UK

30. Department of Psychosis Studies Institute of Psychiatry, Psychology and Neuroscience, King's College London London UK

31. Department of Psychiatry and Psychotherapy Jena University Hospital Jena Germany

32. Department of Psychiatry and Behavioral Sciences and Weill Institute for Neurosciences University of California San Francisco California USA

33. Mental Health Service 116D, Veterans Affairs San Francisco Health Care System San Francisco California USA

34. Department of Psychology Northwestern University Chicago Illinois USA

35. Mental Health Services in the Capital Region Copenhagen Denmark

36. Department of Clinical Medicine Copenhagen University Hospital Copenhagen Denmark

37. Massachusetts General Hospital Harvard Medical School Boston Massachusetts USA

38. Department of Psychiatry IMHAY, University of Chile Santiago Chile

39. PEPP‐Montreal, Douglas Research Centre Montreal Quebec Canada

40. Department of Psychiatry McGill University Montreal Quebec Canada

41. Department of Psychology University of Georgia Athens Georgia USA

42. Shanghai Mental Health Center Shanghai Jiaotong University School of Medicine Shanghai China

43. Department of Psychiatry Icahn School of Medicine at Mount Sinai New York New York USA

44. Department of Psychiatry University of North Carolina Chapel Hill North Carolina USA

45. Department of Psychological Science University of California Irvine California USA

46. Department of Medicine Institute of Biomedical Research (IBSAL), Universidad de Salamanca Salamanca Spain

47. Department of Psychosis Studies King's College London London UK

48. Department of Brain and Behavioral Sciences University of Pavia Pavia Italy

49. Department of Radiology Brigham and Women's Hospital and Harvard Medical School Boston Massachusetts USA

50. Department of Psychiatry, Perelman School of Medicine University of Pennsylvania Philadelphia Pennsylvania USA

51. Department of Software Engineering and Information Technology, École de Technologie Supérieure Université du Québec Montréal Quebec Canada

52. Institute for Mental and Physical Health and Clinical Translation, School of Medicine Deakin University Geelong Victoria Australia

Abstract

AbstractAimTo harmonize two ascertainment and severity rating instruments commonly used for the clinical high risk syndrome for psychosis (CHR‐P): the Structured Interview for Psychosis‐risk Syndromes (SIPS) and the Comprehensive Assessment of At‐Risk Mental States (CAARMS).MethodsThe initial workshop is described in the companion report from Addington et al. After the workshop, lead experts for each instrument continued harmonizing attenuated positive symptoms and criteria for psychosis and CHR‐P through an intensive series of joint videoconferences.ResultsFull harmonization was achieved for attenuated positive symptom ratings and psychosis criteria, and modest harmonization for CHR‐P criteria. The semi‐structured interview, named Positive SYmptoms and Diagnostic Criteria for the CAARMS Harmonized with the SIPS (PSYCHS), generates CHR‐P criteria and severity scores for both CAARMS and SIPS.ConclusionsUsing the PSYCHS for CHR‐P ascertainment, conversion determination, and attenuated positive symptom severity rating will help in comparing findings across studies and in meta‐analyses.

Funder

Wellcome Trust

Publisher

Wiley

Subject

Biological Psychiatry,Psychiatry and Mental health,Pshychiatric Mental Health

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