Affiliation:
1. State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Department of Cariology and Endodontics, West China Hospital of Stomatology Sichuan University Chengdu Sichuan China
2. Institute of Biomedical Engineering, West China School of Basic Medical Sciences & Forensic Medicine Sichuan University Chengdu China
Abstract
AbstractSemaphorin 3A (SEMA3A), also referred to as H‐Sema III, is a molecule with significant biological importance in regulating physiological and pathological processes. However, its role in oral diseases, particularly its association with inflammatory immunity and alveolar bone remodeling defects, remains poorly understood. This comprehensive review article aims to elucidate the recent advances in understanding SEMA3A in the oral system, encompassing nerve formation, periodontitis, pulpitis, apical periodontitis, and oral squamous cell carcinoma. Notably, we explore its novel function in inflammatory immunomodulation and alveolar bone formation during oral infectious diseases. By doing so, this review enhances our comprehension of SEMA3A's role in oral biology and opens up possibilities for modulatory approaches and potential treatments in oral diseases.
Funder
China Postdoctoral Science Foundation
National Natural Science Foundation of China
Subject
General Dentistry,Otorhinolaryngology