Blood–brain barrier dysfunction in aging is mediated by brain endothelial senescence-Reference-Cited by-同舟云学术

Blood–brain barrier dysfunction in aging is mediated by brain endothelial senescence

Published:2024-08-15 Issue:9 Volume:23 Page:
ISSN:1474-9718
Container-title:Aging Cell
language:en
Short-container-title:Aging Cell

Author:

Novo João P.¹²³,Gee Lucy⁴,Caetano Carolina A.¹³,Tomé Inês¹³^ORCID,Vilaça Andreia³⁵,von Zglinicki Thomas⁶,Moreira Irina S.¹³⁷,Jurk Diana⁴^ORCID,Rosa Susana¹³,Ferreira Lino¹³⁵^ORCID

Affiliation:

1. CNC‐UC Center for Neuroscience and Cell Biology University of Coimbra Coimbra Portugal

2. University of Coimbra, Institute for Interdisciplinary Research Doctoral Programme in Experimental Biology and Biomedicine (PDBEB) Coimbra Portugal

3. CIBB—Centre for Innovative Biomedicine and Biotechnology University of Coimbra Coimbra Portugal

4. Department of Physiology and Biomedical Engineering Mayo Clinic Rochester Minnesota USA

5. Faculty of Medicine University of Coimbra Coimbra Portugal

6. Biosciences Institute, Faculty of Medical Sciences Newcastle University Newcastle upon Tyne UK

7. Department of Life Sciences, University of Coimbra Coimbra Portugal

Abstract

AbstractBBB dysfunction during aging is characterized by an increase in its permeability and phenotypic alterations of brain endothelial cells (BECs) including dysregulation of tight junction's expression. Here we have investigated the role of BEC senescence in the dysfunction of the BBB. Our results suggest that the transition from young to aged BBB is mediated, at least in part by BEC senescence.

Funder

Fundação para a Ciência e a Tecnologia

National Institute on Aging

HORIZON EUROPE European Innovation Council

Biotechnology and Biological Sciences Research Council

Publisher

Wiley

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1111/acel.14270

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4. A Stable and Reproducible Human Blood-Brain Barrier Model Derived from Hematopoietic Stem Cells