Mesenchymal stromal cells and CAR‐T cells in regenerative medicine: The homing procedure and their effective parameters

Author:

Kolahi Azar Hanieh12,Imanpour Aylar2,Rezaee Hanieh23,Ezzatifar Fatemeh245,Zarei‐Behjani Zeinab26,Rostami Mohammadreza78,Azami Mahmoud29,Behestizadeh Nima29ORCID,Rezaei Nima101112ORCID

Affiliation:

1. Department of Pathology Tabriz University of Medical Sciences Tabriz Iran

2. Regenerative Medicine group (REMED) Universal Scientific Education and Research Network (USERN) Tehran Iran

3. Department of Medical Biotechnology, School of Advanced Technologies in Medicine Shahid Beheshti University of Medical Sciences Tehran Iran

4. Molecular and Cell Biology Research Center, Department of Immunology, School of Medicine Mazandaran University of Medical Sciences Sari Iran

5. Student Research Committee Mazandaran University of Medical Sciences Sari Iran

6. Department of Tissue Engineering and Applied Cell Sciences, Advanced School of Medical Sciences and Technologies Shiraz University of Medical Sciences Shiraz Iran

7. Division of Food Safety and Hygiene, Department of Environmental Health Engineering, School of Public Health Tehran University of Medical Sciences Tehran Iran

8. Food Science and Nutrition Group (FSAN) Universal Scientific Education and Research Network (USERN) Tehran Iran

9. Department of Tissue Engineering, School of Advanced Technologies in Medicine Tehran University of Medical Sciences Tehran Iran

10. Department of Immunology, School of Medicine Tehran University of Medical Sciences Tehran Iran

11. Research Center for Immunodeficiencies, Children's Medical Center Tehran University of Medical Sciences Tehran Iran

12. Network of Immunity in Infection, Malignancy and Autoimmunity (NIIMA) Universal Scientific Education and Research Network (USERN) Tehran Iran

Abstract

AbstractMesenchymal stromal cells (MSCs) and chimeric antigen receptor (CAR)‐T cells are two core elements in cell therapy procedures. MSCs have significant immunomodulatory effects that alleviate inflammation in the tissue regeneration process, while administration of specific chemokines and adhesive molecules would primarily facilitate CAR‐T cell trafficking into solid tumors. Multiple parameters affect cell homing, including the recipient's age, the number of cell passages, proper cell culture, and the delivery method. In addition, several chemokines are involved in the tumor microenvironment, affecting the homing procedure. This review discusses parameters that improve the efficiency of cell homing and significant cell therapy challenges. Emerging comprehensive mechanistic strategies such as non‐systemic and systemic homing that revealed a significant role in cell therapy remodeling were also reviewed. Finally, the primary implications for the development of combination therapies that incorporate both MSCs and CAR‐T cells for cancer treatment were discussed.

Publisher

Wiley

Subject

Hematology,General Medicine

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