Sorting out release, uptake and processing of alpha-synuclein during prion-like spread of pathology

Author:

Tyson Trevor1,Steiner Jennifer A.1,Brundin Patrik1

Affiliation:

1. Center for Neurodegenerative Science; Van Andel Research Institute; Grand Rapids Michigan USA

Funder

Van Andel Research Institute

Michael J. Fox Foundation for Parkinson's Research

National Institutes of Health

Cure Parkinson’s Trust

TEVA Neuroscience

East Tennessee Foundation

KiMe Fund

Cook Foundation

Campbell Foundation

Renovo Neural, Inc., Roche

Teva/Lundbeck

ClearView Healthcare

FCB Health

IOS Press Partners and Capital Technologies, Inc

Renovo and Teva/Lundbeck

Publisher

Wiley

Subject

Cellular and Molecular Neuroscience,Biochemistry

Reference183 articles.

1. A molecular chaperone complex at the lysosomal membrane is required for protein translocation;Agarraberes;J. Cell Sci.,2001

2. Lysosomal dysfunction increases exosome-mediated alpha-synuclein release and transmission;Alvarez-Erviti;Neurobiol. Dis.,2011

3. Regulated secretion of conventional lysosomes;Andrews;Trends Cell Biol.,2000

4. Role of the mammalian retromer in sorting of the cation-independent mannose 6-phosphate receptor;Arighi;J. Cell Bio.,2004

5. Aggregation of alpha-synuclein in Lewy bodies of sporadic Parkinson's disease and dementia with Lewy bodies;Baba;Am. J. Pathol.,1998

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