Prenatal origin of <scp><i>NUTM1</i></scp> gene rearrangement in infant B‐cell precursor acute lymphoblastic leukaemia-Reference-Cited by-同舟云学术

Prenatal origin of NUTM1 gene rearrangement in infant B‐cell precursor acute lymphoblastic leukaemia

Published:2024-08-05 Issue: Volume: Page:
ISSN:0007-1048
Container-title:British Journal of Haematology
language:en
Short-container-title:Br J Haematol

Author:

Bardini Michela¹^ORCID,Fazio Grazia¹²^ORCID,Abascal Lilia Corral¹,Meyer Claus³^ORCID,Maglia Oscar¹,Sala Simona¹,Palamini Sonia¹,Rebellato Stefano¹^ORCID,Marschalek Rolf²^ORCID,Rizzari Carmelo⁴^ORCID,Biondi Andrea²⁴^ORCID,Cazzaniga Giovanni¹²^ORCID

Affiliation:

1. Tettamanti Center, Fondazione IRCCS San Gerardo Dei Tintori Monza Italy

2. School of Medicine and Surgery, University of Milano‐Bicocca Milano Italy

3. DCAL/Institute of Pharmaceutical Biology, Goethe‐University Frankfurt/Main Germany

4. Pediatrics, Fondazione IRCCS San Gerardo Dei Tintori Monza Italy

Abstract

SummaryRearrangement of NUTM1 gene (NUTM1r) is one of the most frequent aberrations occurring in infants (younger than 1 year at diagnosis) with B‐cell precursor Acute Lymphoblastic Leukaemia (BCP‐ALL). In this study we had the unique opportunity to analyze the umbilical cord blood (UCB) sample from one infant patient with NUTM1r BCP‐ALL. Herein we reported for the first time that NUTM1r infant ALL arise prenatally, as both the patient‐specific CUX1::NUTM1 fusion gene, as well as two IG/TR leukaemic markers were already present and detectable in the patient's UCB at birth. Our results clearly demonstrate the prenatal origin of NUTM1r infant BCP‐ALL.

Publisher

Wiley

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1111/bjh.19685

Reference33 articles.

1. The expanding universe of NUTM1 fusions in pediatric cancer

2. Favorable outcome of NUTM1-rearranged infant and pediatric B cell precursor acute lymphoblastic leukemia in a collaborative international study

3. Recurrent genetic fusions redefine MLL germ line acute lymphoblastic leukemia in infants

4. Cryptic recurrent ACIN1 ‐ NUTM1 fusions in non‐ KMT2A ‐rearranged infant acute lymphoblastic leukemia

5. NUTM1 is a recurrent fusion gene partner in B-cell precursor acute lymphoblastic leukemia associated with increased expression of genes on chromosome band 10p12.31-12.2