Affiliation:
1. Key Laboratory of Biorheological Science and Technology, Ministry of Education, College of Bioengineering Chongqing University Chongqing China
2. Southwest Hospital/Southwest Eye Hospital Third Military Medical University (Army Medical University) Chongqing China
3. School of Basic Medical Sciences/School of Biology and Engineering (School of Modern Industry for Health and Medicine) Guizhou Medical University Guiyang China
Abstract
AbstractCoronavirus disease 2019 (COVID‐19), a global pandemic caused by the severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2), has posed a catastrophic threat to human health worldwide. Human stem cell‐derived organoids serve as a promising platform for exploring SARS‐CoV‐2 infection. Several review articles have summarized the application of human organoids in COVID‐19, but the research status and development trend of this field have seldom been systematically and comprehensively studied. In this review, we use bibliometric analysis method to identify the characteristics of organoid‐based COVID‐19 research. First, an annual trend of publications and citations, the most contributing countries or regions and organizations, co‐citation analysis of references and sources and research hotspots are determined. Next, systematical summaries of organoid applications in investigating the pathology of SARS‐CoV‐2 infection, vaccine development and drug discovery, are provided. Lastly, the current challenges and future considerations of this field are discussed. The present study will provide an objective angle to identify the current trend and give novel insights for directing the future development of human organoid applications in SARS‐CoV‐2 infection.
Funder
National Natural Science Foundation of China
Natural Science Foundation of Chongqing Municipality
Subject
Cell Biology,General Medicine
Cited by
2 articles.
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