Endometriosis‐Associated Infertility: Double Intrauterine Insemination Improves Fecundity in Patients Positive for Antiendometrial Antibodies

Author:

Subit Michael,Gantt Pickens,Broce Mike,Seybold Dara J.,Randall Gary

Abstract

Citation 
Subit M, Gantt P, Broce M, Seybold DJ, Randall G. Endometriosis‐associated infertility: double intrauterine insemination improves fecundity in patients positive for antiendometrial antibodies. Am J Reprod Immunol 2011; 66: 100–107Problem  Prospective registry study evaluating effects of endometriosis (E) and serum antiendometrial antibodies (AEA) on fecundity in intrauterine insemination (IUI) cycles.Method of study  AEA assays on 572 consecutive women receiving 969 single and 274 double IUI cycles. Logistic regression was utilized.Results  Fecundity was 11.5% (143/1243 cycles). Double IUI improved fecundity with significance achieved in certain study groups. Compared to the AEA− subgroup, all study groups except for the E+ AEA− group had significantly lower fecundity. Two study groups receiving double IUI had significantly increased fecundity, E− AEA+ (OR: 5.1, CI: 1.1–22.7, P = 0.032) and E+ AEA+ (OR: 4.1, CI: 1.2–14.0, P = 0.025) and significant predictors of pregnancy (E− AEA+, OR: 7.8, CI: 1.7–36.2, P = 0.009 and E+ AEA+, OR: 4.2, CI: 1.2–15.1, P = 0.026).Conclusion  Double IUI improves fecundity in AEA+ patients. E‐associated infertility is better diagnosed by the AEA assay than by surgery. Double IUI should be attempted prior to assisted reproductive technologies in AEA+ patients with normal fallopian tubes.

Publisher

Wiley

Cited by 3 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. Endometriosis and inflammatory immune responses: Indian experience;American Journal of Reproductive Immunology;2022-07

2. The Impact of Autoantibodies on IVF Treatment and Outcome: A Systematic Review;International Journal of Molecular Sciences;2019-02-19

3. Consensus on current management of endometriosis;Human Reproduction;2013-03-25

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