Affiliation:
1. Universidad Europea de Valencia, Faculty of Health Sciences Department of Dentistry Valencia España Spain
2. Department of Pharmacy Pharmaceutical Technology and Parasitology, Faculty of Pharmacy and Food Sciences, University of Valencia, Av. Vicent Andrés Estellés s/n Valencia Spain
3. Interuniversity Research Institute for Molecular Recognition and Technological Development (IDM) University of Valencia, Polytechnic University of Valencia, Av. Vicent A. Estellés s/n Valencia Spain
Abstract
AbstractIntroductionOral submucous fibrosis (OSMF) is a well‐known precancerous oral lesion, characterized by scarring, tissue fibrosis, and premalignant lesions. The goal of clinical treatment is to reduce inflammation and improve patients' quality of life by enhancing mouth opening among others. Antioxidant treatment has shown promising results in inducing regression of lesions and preventing OSMF in high‐risk individuals. This study investigates the effectiveness of various antioxidant agents against OSMF.Materials and MethodsThe study followed PRISMA guidelines and searched three scientific databases: PubMed, Web of Science, and Scopus, using specific algorithms related to “antioxidant treatment,” “burning sensation,” and “mouth opening.” The quality assessment of controlled clinical studies adhered to Cochrane guidelines.ResultsThe analysis included 19 clinical trials comparing different treatments, including various antioxidants. Aloe vera, curcumin, and lycopene, among others, showed positive outcomes in treating OSMF by improving burning sensation, mouth opening, tongue protrusion, and cheek flexibility.ConclusionAntioxidant therapies are found to be effective in treating OSMF, even when compared to conventional treatments such as corticosteroids. The study highlights the need for further research and standardization of clinical protocols.
Subject
Periodontics,Cancer Research,Otorhinolaryngology,Oral Surgery,Pathology and Forensic Medicine