Affiliation:
1. Molecular Biology Laboratory School of Medicine Universidade Federal do Rio Grande Rio Grande Rio Grande do Sul Brazil
2. Center for Obstetrics and Gynecology School of Medicine Universidade Federal do Rio Grande Rio Grande Rio Grande do Sul Brazil
3. Oncovirology Program Instituto Nacional do Câncer (INCA) Rio de Janeiro Rio de Janeiro Brazil
Abstract
ProblemHerpes simplex virus 1 (HSV‐1) commonly causes orolabial infection, but can also infect the genital mucosa. In contrast, HSV‐2 is usually genital. Genital herpes can transmit the virus vertically to the fetus during pregnancy. We sought to estimate the prevalence of HSV‐1/2 on the maternal and fetal sides of the placenta.Method of studyPlacental tissues were collected from pregnant women seen at the Rio Grande University Hospital. HSV‐1 and HSV‐2 were detected by nested PCR.ResultsThe prevalence of HSV‐1 and HSV‐2 was, respectively, 28% and 12.6% (maternal side) and 29.9% and 8.3% (fetal side). All HSV‐positive women were asymptomatic. Sexual behavior, vaginal delivery, and presence of HSVs on one side of the placenta were risk factors associated with HSV infection.ConclusionThe occurrence of HSVs in placental tissue was high, especially for HSV‐1. Novel strategies need to be implemented for the management of asymptomatic women who might transmit HSV to their newborns.
Funder
Fundação de Amparo à Pesquisa do Estado do Rio Grande do Sul
Conselho Nacional de Desenvolvimento Científico e Tecnológico
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