A non‐covalent inhibitor XMU‐MP‐3 overrides ibrutinib‐resistant Btk C481S mutation in B‐cell malignancies

Author:

Gui Fu1,Jiang Jie1,He Zhixiang1,Li Li1,Li Yunzhan1,Deng Zhou1,Lu Yue1,Wu Xinrui1,Chen Guyue1,Su Jingyi1,Song Siyang1,Zhang Yue‐Ming2,Yun Cai‐Hong2,Huang Xin3,Weisberg Ellen4,Zhang Jianming56,Deng Xianming1ORCID

Affiliation:

1. State Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Signaling Network, State‐Province Joint Engineering Laboratory of Targeted Drugs from Natural Products, School of Life ScienceXiamen University Xiamen China

2. Institute of Systems Biomedicine, Department of Biophysics and Beijing Key Laboratory of Tumor Systems Biology, School of Basic Medical SciencesPeking University Health Science Center Beijing China

3. Division of Drug Discovery, Hongyun Biotech Co., Ltd. Nanjing China

4. Department of Medical Oncology, Dana Farber Cancer InstituteHarvard Medical School Boston Massachusetts

5. National Research Center for Translational Medicine, Shanghai State Key Laboratory of Medical Genomics, Rui‐Jin HospitalShanghai JiaoTong University School of Medicine Shanghai China

6. Cutaneous Biology Research Center, Massachusetts General HospitalHarvard Medical School Boston Massachusetts

Funder

Fundamental Research Funds for the Central Universities

Project 211

National Natural Science Foundation of China

Ministry of Science and Technology of the People's Republic of China

Publisher

Wiley

Subject

Pharmacology

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