Affiliation:
1. The First Clinical Medical College Lanzhou University Lanzhou People's Republic of China
2. The First Hospital of Lanzhou University Lanzhou People's Republic of China
3. Key Laboratory for Reproductive Medicine and Embryo of Gansu Province Lanzhou People's Republic of China
4. Gansu Provincial Maternity and Child‐care Hospital (Gansu Province Central Hospital) Lanzhou People's Republic of China
5. Evidence‐Based Medicine Center, School of Basic Medical Sciences Lanzhou University Lanzhou People's Republic of China
Abstract
AbstractAimTo explore the effect of embryo selection using the time‐lapse monitoring (TLM) system compared with conventional morphological selection (CMS) on in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI) outcomes.MethodsWe searched PubMed, Ovid‐Embase, and The Cochrane Library for the following studies: At Comparison 1, embryo selection using TLM images in a TLM incubator based on morphology versus embryo selection using CMS in a conventional incubator based on morphology; at Comparison 2, embryo selection using TLM based on morphokinetics versus embryo selection using CMS based on morphology. The primary outcomes were the live birth rate (LBR), ongoing pregnancy rate (OPR), clinical pregnancy rate (CPR), and implantation rate (IR), and the secondary outcome was the miscarriage rate (MR).ResultsA total of 14 randomized control trials (RCTs) were included. Both based on morphology, TLM incubators increased the IR (risk ratio [RR]: 1.10; 95% confidence interval [CI]: 1.01, 1.18; I2 = 0%, moderate‐quality evidence) compared to conventional incubators. Low‐ to moderate‐quality evidence suggests that TLM incubators did not improve LBR, OPR, CPR, and MR compared to conventional incubators. In addition, low‐ to moderate‐quality evidence indicates that embryo selection using TLM based on morphokinetics did not improve LBR, OPR, CPR, IR, or MR compared to CMS based on morphology.ConclusionsLow‐ to moderate‐quality evidence suggests that neither TLM incubators nor embryo selection using TLM based on morphokinetics improved clinical outcomes (LBR, OPR, CPR, and MR) compared with CMS based on morphology. TLM is still an investigational procedure for IVF/ICSI practice.
Subject
Obstetrics and Gynecology
Cited by
1 articles.
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