Affiliation:
1. Department of Dermatology Tianjin Academy of Traditional Chinese Medicine Affiliated Hospital Tianjin China
2. Department of Dermatology, Tongren Hospital Shanghai Jiaotong University, School of Medicine Shanghai China
3. Department of Dermatology The First Affiliated Hospital of Soochow University Suzhou China
4. Dermatology Hospital Southern Medical University Guangzhou China
Abstract
AbstractInflammatory dermatoses such as atopic dermatitis (AD) have long been linked to the pathogenesis of diabetes mellitus. Indeed, numerous studies show an increased risk of diabetes mellitus in individuals with AD although lower prevalence of diabetes mellitus is also observed in few studies. Though the underlying mechanisms accounting for the reciprocal influence between these two conditions are still unclear, the complex interplay between diabetes mellitus and AD is attributable, in part, to genetic and environmental factors, cytokines, epidermal dysfunction, as well as drugs used for the treatment of AD. Proper management of one condition can mitigate the other condition. In this review, we summarize the evidence of the interaction between diabetes mellitus and AD, and discuss the possible underlying mechanisms by which these two conditions influence each other.