Evaluating the efficacy of recombinant human growth factors in scar remodelling for patients with facial soft tissue injuries

Author:

Zhang Baiyu12,He Zonghai1,Zhao Hui1,Gao Hongbin1,Zhang Zhiying1,Gao Zhenhua12ORCID,Ke Kunbin1

Affiliation:

1. The First Department of Urology The First Affiliated Hospital of Kunming Medical University Kunming China

2. Yunnan Province Clinical Research Center for Chronic Kidney Disease Kunming China

Abstract

AbstractFacial soft tissue injuries, often resulting in scarring, pose a challenge in reconstructive and aesthetic surgery due to the need for functional and aesthetic restoration. This study evaluates the efficacy of recombinant human growth factors (rhGFs) in scar remodelling for such injuries. A retrospective evaluation was conducted from January 2020 to January 2023, involving 100 patients with facial soft tissue injuries. Participants were divided equally into a control group, receiving standard cosmetic surgical repair, and an observation group, treated with rhGFs supplemented cosmetic surgery. The study assessed scar characteristics (pigmentation, pliability, vascularity, height), hospital stay duration, tissue healing time, complication rates and patient satisfaction. The observation group demonstrated significant improvements in all scar characteristics, with notably better pigmentation, pliability, vascularity and height compared with the control group. The rhGF treatment also resulted in reduced hospital stay duration and faster tissue healing. Notably, the total complication rate was significantly lower in the observation group (10%) compared with the control group (34%). Additionally, patient satisfaction levels were higher in the observation group, with 98% combined satisfaction compared with 76% in the control group. The application of rhGFs in treating facial soft tissue injuries significantly enhances scar remodelling, expedites healing, reduces complications and improves patient satisfaction. These findings establish rhGFs as a valuable tool in the management of facial soft tissue injuries, highlighting their potential in improving both functional and aesthetic outcomes.

Publisher

Wiley

Subject

Dermatology,Surgery

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