Recommendations for the treatment and management of adult B‐Cell acute lymphoblastic leukemia in Asia‐Pacific: Outcomes from a pilot initiative

Author:

Lao Zhentang1,Lam Kwong Yok2,Cheung Yuk Man Carol2,Teng Chieh‐Lin3,Radhakrishnan Vivek4,Bhurani Dinesh5,Ko Bor‐Sheng6ORCID,Goh Yeow Tee1

Affiliation:

1. Department of Haematology Singapore General Hospital Singapore Singapore

2. Department of Medicine Queen Mary Hospital University of Hong Kong Hong Kong China

3. Department of Medicine Division of Hematology/Medical Oncology Taichung Veterans General Hospital Taichung Taiwan

4. Division of Haematology Oncology and Haematopoietic Cell Transplantation Tata Medical Center Kolkata India

5. Department of Hematology and Bone Marrow Transplant Rajiv Gandhi Cancer Institute & Research Centre New Delhi India

6. Department of Hematological Oncology National Taiwan University Cancer Center Taipei Taiwan

Abstract

AbstractThe outcomes of adult B‐cell acute lymphoblastic leukemia (ALL) remain poor. Recent advancements in the field of leukemia research show potential for improved patient care. However, the adoption of research findings into clinical practice is fraught with practice‐ and country‐specific challenges. The continued addition of new findings warrants critical evaluation for the feasibility of incorporation into clinical practice. A uniform set of evidence‐based guidelines can favorably assist physicians in making optimal clinical decisions. Such a resource may also serve as a reference point for strategic planning of initiatives aimed at addressing critical barriers in the optimal management of B‐cell ALL. This initiative was undertaken to seek a collaborative perspective and understand the existing challenges. Concordance‐based recommendations were outlined through a systematic discussion on various aspects of treatment and management of adult B‐cell ALL. The outcomes and experiences gained from this exercise will serve as a foundation for future efforts encompassing the more granular aspects of the management of B‐cell ALL across the Asia‐Pacific region.

Publisher

Wiley

Subject

Oncology,General Medicine

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