Affiliation:
1. Department of Gynecology The Second People's Hospital of Liaocheng Linqing 252600 China
2. Department of Gynecology The Second Hospital of Liaocheng Affiliated to Shandong First Medical University Linqing 252600 China
Abstract
AbstractAimApatinib is an effective treatment for patients with gynecological cancers. This study aimed to further explore the efficacy and safety of apatinib plus chemotherapy in patients with recurrent platinum‐resistant ovarian cancer (PROC).MethodsTotally, 105 patients with recurrent PROC receiving apatinib plus chemotherapy (N = 51) and chemotherapy alone (N = 54) were retrospectively enrolled in this cohort study.ResultsObjective response rate (37.3% vs. 14.8%) (p = 0.009) and disease control rate (80.4% vs. 61.1%) (p = 0.030) were increased in the apatinib plus chemotherapy group versus the chemotherapy group. The median (95% confidence interval [CI]) progression‐free survival (PFS) and overall survival (OS) were 5.5 (3.4–7.6) and 21.4 (16.2–26.6) months in the apatinib plus chemotherapy group, and they were 3.8 (3.0–4.6) and 14.8 (11.9–17.7) months in the chemotherapy group. Meanwhile, the Kaplan–Meier curves revealed that PFS (p = 0.008) and OS (p = 0.012) were prolonged in the apatinib plus chemotherapy group versus the chemotherapy group. This finding was confirmed by multivariate Cox's proportional regression analyses: enter method (hazard ratio [HR] = 0.515, p = 0.007 for PFS; HR = 0.222, p < 0.001 for OS) and step‐forward method (HR = 0.608, p = 0.019 for PFS; HR = 0.346, p = 0.001 for OS). Additionally, the incidence of hypertension was increased in the apatinib plus chemotherapy group versus the chemotherapy group (p = 0.038), while others were not different between the two groups (all p > 0.05). Grades 3 and 4 adverse events were neutropenia, hypertension, leukopenia, hand–foot syndrome, nausea and vomiting, fatigue, thrombocytopenia, and anemia in the apatinib plus chemotherapy group.ConclusionApatinib combined with chemotherapy is a superior choice over chemotherapy alone for recurrent PROC management.
Subject
Obstetrics and Gynecology