GRADE pearls and pitfalls—Part 1: Systematic reviews and meta‐analyses

Author:

Al Duhailib Zainab123ORCID,Granholm Anders24ORCID,Alhazzani Waleed2567,Oczkowski Simon267,Belley‐Cote Emilie2678,Møller Morten Hylander249

Affiliation:

1. Department of Critical Care Medicine King Faisal Specialist Hospital & Research Centre Riyadh Saudi Arabia

2. Guidelines in Intensive Care Medicine, Development and Evaluation (GUIDE) Group Hamilton Ontario Canada

3. Department of Medicine Alfaisal University Riyadh Saudi Arabia

4. Department of Intensive Care Copenhagen University Hospital—Rigshospitalet Copenhagen Denmark

5. Department of Critical Care, College of Medicine King Saud University Riyadh Saudi Arabia

6. Department of Medicine McMaster University Hamilton Ontario Canada

7. Department of Health Research Methods, Evidence, and Impact McMaster University Hamilton Ontario Canada

8. Public Health Research Institute Hamilton Ontario Canada

9. Department of Clinical Medicine University of Copenhagen Copenhagen Denmark

Abstract

AbstractBackgroundThe Grading of Recommendation, Assessment, Development and Evaluation (GRADE) approach is used to assess the certainty of evidence in systematic reviews and meta‐analyses.MethodsWe describe how the GRADE approach is used in systematic reviews and meta‐analyses, including key points and examples. This overview is aimed at clinicians and researchers who are, or plan to be, involved in the development or assessment of systematic reviews with meta‐analyses using GRADE.ResultsWe outline how the certainty of evidence is assessed, how the evidence is summarized using GRADE evidence profiles or summary of findings tables, how the results are communicated, and we discuss challenges, advantages, and disadvantages with using GRADE.ConclusionsThis overview aims to provide an overview of how GRADE is used in systematic reviews and meta‐analyses, and may be used by systematic review developers, methodologists, and evidence end‐users.

Publisher

Wiley

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