Hypertonicity and/or acidosis induce marked rheological changes under hypoxic conditions in sickle trait red blood cells-Reference-Cited by-同舟云学术

Hypertonicity and/or acidosis induce marked rheological changes under hypoxic conditions in sickle trait red blood cells

Published:2024-07-25 Issue: Volume: Page:
ISSN:0007-1048
Container-title:British Journal of Haematology
language:en
Short-container-title:Br J Haematol

Author:

Ellsworth Patrick¹²^ORCID,Pawlinski Izabela J.¹,Sielaty Rachel¹,Ilich Anton¹,Prokopenko Yuriy¹,Moonla Chatphatai¹³,Monroe Dougald M.¹²,Pawlinski Rafal¹²,Key Nigel S.¹²^ORCID

Affiliation:

1. UNC Blood Research Center, University of North Carolina at Chapel Hill Chapel Hill North Carolina USA

2. Division of Hematology, Department of Medicine University of North Carolina at Chapel Hill Chapel Hill North Carolina USA

3. Department of Medicine and Center of Excellence in Translational Hematology, Faculty of Medicine Chulalongkorn University and King Chulalongkorn Memorial Hospital Bangkok Thailand

Abstract

SummaryDeformability and sickling of red blood cells (RBCs) from individuals with sickle cell trait (SCT) was evaluated under harsh biophysical conditions that mimic certain vascular beds in vivo. RBC deformability in osmotic‐gradient ektacytometry was decreased in HbAS (SCT) compared to HbAA (wild‐type) RBCs at supraphysiological osmolalities. RBC deformability was also measured by oxygen‐gradient ektacytometry. Whereas RBC sickling was not observed under isotonic and neutral pH conditions, hypertonicity and acidosis alone or in combination induced reversible sickling of SCT RBC. These data suggest that hyperosmolality and/or acidosis enhance hypoxia‐induced sickling of SCT RBC.

Funder

National Institutes of Health

Publisher

Wiley

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1111/bjh.19669

Reference15 articles.

1. Negative health implications of sickle cell trait in high income countries: from the football field to the laboratory

2. Effects of hydration and dehydration on blood rheology in sickle cell trait carriers during exercise

3. Pathophysiological Relevance of Renal Medullary Conditions on the Behaviour of Red Cells From Patients With Sickle Cell Anaemia

4. The α-Globin Genotype as a Determinant of Hematologic Parameters in Sickle Cell Trait

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