Real world population pharmacokinetic study in children and young adults with inflammatory bowel disease discovers novel blood and stool microbial predictors of vedolizumab clearance

Author:

Colman Ruben J.12ORCID,Mizuno Tomoyuki34ORCID,Fukushima Keizo3ORCID,Haslam David B.45ORCID,Hyams Jeffrey S.6ORCID,Boyle Brendan7,Noe Joshua D.8,D'Haens Geert R.9ORCID,Van Limbergen Johan210ORCID,Chun Kelly11,Yang Jane11,Denson Lee A.14ORCID,Ollberding Nicholas J.412ORCID,Vinks Alexander A.34ORCID,Minar Phillip14ORCID

Affiliation:

1. Division of Gastroenterology, Hepatology, and Nutrition Cincinnati Children's Hospital Medical Center Cincinnati Ohio USA

2. Department of Pediatric Gastroenterology and Nutrition Amsterdam University Medical Centers – Location University of Amsterdam, Emma Children's Hospital Amsterdam The Netherlands

3. Division of Clinical Pharmacology Cincinnati Children's Hospital Medical Center Cincinnati Ohio USA

4. Department of Pediatrics University of Cincinnati College of Medicine Cincinnati Ohio USA

5. Division of Infectious Diseases Cincinnati Children's Hospital Medical Center Cincinnati Ohio USA

6. Division of Digestive Diseases, Hepatology and Nutrition Connecticut Children's Medical Center Cincinnati Ohio USA

7. Division of Gastroenterology, Hepatology and Nutrition Nationwide Children's Hospital Columbus Ohio USA

8. Division of Gastroenterology, Hepatology and Nutrition Children's Hospital of Wisconsin Wauwatosa Wisconsin USA

9. Gastroenterology and Hepatology Amsterdam University Medical Centers – Location University of Amsterdam Amsterdam The Netherlands

10. Tytgat Institute for Liver and Intestinal Research, Amsterdam Gastroenterology Endocrinology Metabolism University of Amsterdam Amsterdam The Netherlands

11. Esoterix LabCorp Burlington North Carolina USA

12. Division of Biostatistics and Epidemiology Cincinnati Children's Hospital Medical Center Cincinnati Ohio USA

Funder

National Center for Advancing Translational Sciences

National Institute of Diabetes and Digestive and Kidney Diseases

Publisher

Wiley

Subject

Pharmacology (medical),Gastroenterology,Hepatology

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