Association of UGT1A1*6 , UGT1A1*28 , or ABCC2 c.3972C>T genetic polymorphisms with irinotecan‐induced toxicity in Asian cancer patients: Meta‐analysis

Author:

Atasilp Chalirmporn1,Biswas Mohitosh234,Jinda Pimonpan23,Nuntharadthanaphong Nutthan23,Rachanakul Jiratha23,Hongkaew Yaowaluck5,Vanwong Natchaya6,Saokaew Surasak789,Sukasem Chonlaphat2310

Affiliation:

1. Chulabhorn International College of Medicine Thammasat University Pathum Thani Thailand

2. Division of Pharmacogenomics and Personalized Medicine, Department of Pathology Faculty of Medicine Ramathibodi Hospital, Mahidol University Bangkok Thailand

3. Laboratory for Pharmacogenomics, Somdech Phra Debaratana Medical Center (SDMC), Ramathibodi Hospital Bangkok Thailand

4. Department of Pharmacy University of Rajshahi Rajshahi Bangladesh

5. Advance Research and Development Laboratory Bumrungrad International Hospital Bangkok Thailand

6. Department of Clinical Chemistry, Faculty of Allied Health Sciences Chulalongkorn University Bangkok Thailand

7. Division of Pharmacy Practice, Department of Pharmaceutical Care School of Pharmaceutical Sciences, University of Phayao Phayao Thailand

8. Center of Health Outcomes Research and Therapeutic Safety (COHORTS) School of Pharmaceutical Sciences, University of Phayao Phayao Thailand

9. Unit of Excellence on Clinical Outcomes Research and Integration (UNICORN) School of Pharmaceutical Sciences, University of Phayao Phayao Thailand

10. Pharmacogenomics and Precision Medicine, The Preventive Genomics & Family Check‐up Services Center Bumrungrad International Hospital Bangkok Thailand

Publisher

Wiley

Subject

General Pharmacology, Toxicology and Pharmaceutics,General Biochemistry, Genetics and Molecular Biology,General Medicine,General Neuroscience

Reference80 articles.

1. Initial Therapy with FOLFOXIRI and Bevacizumab for Metastatic Colorectal Cancer

2. Irinotecan combined with fluorouracil compared with fluorouracil alone as first-line treatment for metastatic colorectal cancer: a multicentre randomised trial

3. Bioactivation of the anticancer agent CPT‐11 to SN‐38 by human hepatic microsomal carboxylesterases and the in vitro assessment of potential drug interactions;Slatter JG;Drug Metab Dispos,1997

4. Irinotecan treatment in cancer patients with UGT1A1 polymorphisms;Innocenti F;Oncology (Williston Park),2003

5. Clinical pharmacokinetics and metabolism of irinotecan (CPT‐11);Mathijssen RH;Clin Cancer Res,2001

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