Testosterone administration inhibits hepcidin transcription and is associated with increased iron incorporation into red blood cells

Author:

Guo Wen1,Bachman Eric1,Li Michelle1,Roy Cindy N.2,Blusztajn Jerzy3,Wong Siu1,Chan Stephen Y.4,Serra Carlo1,Jasuja Ravi1,Travison Thomas G.1,Muckenthaler Martina U.5,Nemeth Elizabeta6,Bhasin Shalender1

Affiliation:

1. Section of Endocrinology, Diabetes, and Nutrition; Boston University School of Medicine; Boston Claude D. Pepper Older Americans Independence Center; Boston Medical Center; Boston; MA; 02118; USA

2. Division of Geriatric Medicine and Gerontology; Johns Hopkins University; Room 2A.44, 5501 Hopkins Bayview Circle; Baltimore; MD; 21224; USA

3. Woods Hole Oceanographic Institution; 266 Woods Hole Rd. MS# 25; Woods Hole; MA; 02543-1050; USA

4. Division of Cardiovascular Medicine; Department of Medicine; Brigham and Women's Hospital; Boston; MA; 02115; USA

5. Department of Molecular Medicine; University of Heidelberg; Otto-Meyerhof-Zentrum; Im Neuenheimer Feld 350; 69120; Heidelberg; Germany

6. Center for Iron Disorders; Division of Pulmonary and Critical Care Medicine; David Geffen School of Medicine at UCLA; CHS 52-239, 10833 Le Conte Ave; Los Angeles; CA; 90095-1690; USA

Publisher

Wiley

Subject

Cell Biology,Aging

Reference38 articles.

1. BMP6 is a key endogenous regulator of hepcidin expression and iron metabolism;Andriopoulos;Nat. Genet.,2009

2. Testosterone suppresses hepcidin in men: a potential mechanism for testosterone-induced erythrocytosis;Bachman;J. Clin. Endocrinol. Metab.,2010

3. Dynamic regulation of circulating microRNA during acute exhaustive exercise and sustained aerobic exercise training;Baggish;J. Physiol.,2011

4. Testosterone and synthetic androgens improve the in vitro survival of human marrow progenitor cells in serum-free suspension cultures;Beran;J. Lab. Clin. Med.,1982

5. Testosterone therapy in men with androgen deficiency syndromes: an Endocrine Society clinical practice guideline;Bhasin;J. Clin. Endocrinol. Metab.,2010

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