Novel Variants in theMC4RandLEPRGenes among Severely Obese Children from the Iberian Population

Author:

Albuquerque David1,Estévez Manuela Núñez2,Víbora Pilar Beato3,Giralt Plácida Sánchez3,Balsera Aránzazu Margallo4,Cortés Pedro Gil3,López Mercedes Jiménez5,Luego Luis Miguel3,Gervasini Guillermo5,Hernández Sergio Barroso6,Arroyo-Díez Javier2,Vacas Manuel Arrobas6,Nóbrega Clévio7,Manco Licínio1,Rodríguez-López Raquel4

Affiliation:

1. Research Centre for Anthropology and Health (CIAS); Department of Life Sciences; University of Coimbra; Portugal

2. Unit of Genetic Paediatrics; Maternal and Child; Badajoz Spain

3. Department of Dietician; Endocrinologist Service; Infanta Cristina Hospital; Badajoz Spain

4. Genetics Unit; Infanta Cristina Hospital; Badajoz Spain

5. Department of Medical & Surgical Therapeutics; Medical School; University of Extremadura; Badajoz Spain

6. Nephrology Service; Infanta Cristina Hospital; Badajoz Spain

7. Center for Neurosciences & Cell Biology; University of Coimbra; Portugal

Funder

ISCIII, Madrid for Financial

Fundesalud, Junta de Extremadura

Fundação para a Ciência e Tecnologia

FCT

Publisher

Wiley

Subject

Genetics (clinical),Genetics

Reference48 articles.

1. A method and server for predicting damaging missense mutations;Adzhubei;Nat Methods,2010

2. Medical sequencing at the extremes of human body mass;Ahituv;Am J Hum Genet,2007

3. The metabolic syndrome-a new worldwide definition;Alberti;Lancet,2005

4. Assessment of obesity and abdominal obesity among Portuguese children;Albuquerque;Acta Med Port,2012

5. Screening for melanocortin-4 receptor mutations in a cohort of Belgian morbidly obese adults and children;Beckers;Int J Obes,2006

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