Affiliation:
1. Centre for Liver and Digestive Disorders, Royal Infirmary of Edinburgh Edinburgh UK
2. Department of Gastroenterology and Hepatology, Austin Health Melbourne Australia
3. Digestive Disease Research Center Medical University of South Carolina Charleston South Carolina USA
4. The University of Melbourne Melbourne Australia
5. College of Medicine and Veterinary Medicine University of Edinburgh Edinburgh UK
Abstract
SummaryBackgroundAdvanced chronic liver disease is an increasing cause of premature morbidity and mortality in the UK. Portal hypertension is the primary driver of decompensation, including the development of ascites, hepatic encephalopathy and variceal haemorrhage. Non‐selective beta blockers (NSBB) reduce portal pressure and are well established in the prevention of variceal haemorrhage. Carvedilol, a newer NSBB, is more effective at reducing portal pressure due to additional α‐adrenergic blockade and has additional anti‐oxidant, anti‐inflammatory and anti‐fibrotic effects.AimTo summarise the available evidence on the use of beta blockers, specifically carvedilol, in cirrhosis, focussing on when and why to startMethodsWe performed a comprehensive literature search of PubMed for relevant publications.ResultsInternational guidelines advise the use of NSBB in primary prophylaxis against variceal haemorrhage in those with high‐risk varices, with substantial evidence of efficacy comparable with endoscopic band ligation (EBL). NSBB are also well established in secondary prophylaxis, in combination with EBL. More controversial is their use in patients without large varices, but with clinically significant portal hypertension. However, there is gathering evidence that NSBB, particularly carvedilol, reduce the risk of decompensation and improve survival. While caution is advised in patients with advanced cirrhosis and refractory ascites, recent evidence suggests that NSBB can continue to be used safely, and that premature discontinuation may be detrimental.ConclusionsWith increasing evidence of benefit independent of variceal bleeding, namely retardation of decompensation and improvement in survival, it is time to consider whether carvedilol should be offered to all patients with advanced chronic liver disease.
Subject
Pharmacology (medical),Gastroenterology,Hepatology
Cited by
5 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献